Literature DB >> 7986209

Aminotriazole is a potent inhibitor of alpha-oxidation of 3-methyl-substituted fatty acids in rat liver.

M Casteels1, K Croes, P P Van Veldhoven, G P Mannaerts.   

Abstract

The production of CO2 and formate in isolated rat hepatocytes incubated in the presence of 3-methyl[1-14C]margaric acid was investigated. Production rates of formate were approximately 4-fold lower than those of CO2. Aminotriazole (3-amino-1, 2, 4-triazole), an irreversible inhibitor of catalase, potently suppressed alpha-oxidation of 3-methylmargaric acid, whereas beta-oxidation of palmitate, 2-methylpalmitate and trihydroxycoprostanic acid and conversion of exogenously added formate to CO2 were not or only slightly affected. This shows that aminotriazole is not only an inhibitor of catalase, but also of alpha-oxidation of 3-methyl-substituted fatty acids.

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Year:  1994        PMID： 7986209     DOI： 10.1016/0006-2952(94)90596-7

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  7 in total

1.  Alpha-oxidation of 3-methyl-branched fatty acids: a revised pathway confined to peroxisomes.

Authors:  K Croes; P P Van Veldhoven; G P Mannaerts; M Casteels
Journal:  Lipids       Date:  1999       Impact factor: 1.880

2.  Peroxisomal localization of alpha-oxidation in human liver.

Authors:  M Casteels; K Croes; P P Van Veldhoven; G P Mannaerts
Journal:  J Inherit Metab Dis       Date:  1997-09       Impact factor: 4.982

3.  Identification of a novel PEX14 mutation in Zellweger syndrome.

Authors:  Sofie J Huybrechts; Paul P Van Veldhoven; Ilse Hoffman; Renate Zeevaert; Rita de Vos; Philippe Demaerel; Marijke Brams; Jaak Jaeken; Marc Fransen; David Cassiman
Journal:  BMJ Case Rep       Date:  2009-01-23

4.  Ataxia associated with increased plasma concentrations of pristanic acid, phytanic acid and C27 bile acids but normal fibroblast branched-chain fatty acid oxidation.

Authors:  P T Clayton; A W Johnson; K A Mills; G W Lynes; J Wilson; M Casteels; G Mannaerts
Journal:  J Inherit Metab Dis       Date:  1996       Impact factor: 4.982

5.  Intermediates and products formed during fatty acid alpha-oxidation in cucumber (Cucumis sativus).

Authors:  G I Borge; G Vogt; A Nilsson
Journal:  Lipids       Date:  1999-07       Impact factor: 1.880

6.  Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids.

Authors:  V Foulon; V D Antonenkov; K Croes; E Waelkens; G P Mannaerts; P P Van Veldhoven; M Casteels
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-31       Impact factor: 11.205

7.  3-Amino-1,2,4-Triazole Induces Quick and Strong Fat Loss in Mice with High Fat-Induced Metabolic Syndrome.

Authors:  Valéria Nunes-Souza; Nelson Miguel Dias-Júnior; Marcos Antônio Eleutério-Silva; Vanessa P Ferreira-Neves; Fabiana Andréa Moura; Natalia Alenina; Michael Bader; Luíza A Rabelo
Journal:  Oxid Med Cell Longev       Date:  2020-04-13       Impact factor: 6.543
  7 in total

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