| Literature DB >> 7984514 |
P D Senanayake1, A Moriguchi, H Kumagai, D Ganten, C M Ferrario, K B Brosnihan.
Abstract
We determined the levels of angiotensin I (ANG I), angiotensin II (ANG II), and the heptapeptide angiotensin(1-7) [ANG(1-7)] in the blood and brain of female Hannover Sprague-Dawley (SD) and transgenic hypertensive rats [mRen-2]27 by radioimmunoassay and high performance liquid chromatography. Hypertension was accompanied by higher plasma concentrations of ANG II, no statistical changes in ANG(1-7), and no differences in plasma ANG I levels. In the hypothalamus of transgenic rats, concentrations of ANG II and ANG(1-7) averaged 827% and 168% above values in SD rats (p < 0.005) whereas both ANG I and ANG II increased in the medulla oblongata. The data showed that the established phase of hypertension in rats harboring the mouse Ren-2 gene is associated with overexpression of the renin-angiotensin system in brain regions participating in the endocrine regulation of blood pressure.Entities:
Mesh：
Substances：
Year: 1994 PMID： 7984514 DOI： 10.1016/0196-9781(94)90051-5
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750