Literature DB >> 7983764

Immunization with nonstructural proteins E1 and E2 of cottontail rabbit papillomavirus stimulates regression of virus-induced papillomas.

R Selvakumar1, L A Borenstein, Y L Lin, R Ahmed, F O Wettstein.   

Abstract

Cottontail rabbit papillomavirus is the major animal model for cancer-associated papillomaviruses. Here we show that vaccination with the nonstructural proteins E1 and E2 induces the regression of virus-induced papillomas and that vaccination is equally effective when proteins are given with and without adjuvant. There was no correlation between antibody levels and regression, suggesting that tumor regression may be due to a cell-mediated response.

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Year:  1995        PMID： 7983764      PMCID： PMC188618          DOI： 10.1128/JVI.69.1.602-605.1995

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  24 in total

1.  STUDIES ON THE MECHANISM RESPONSIBLE FOR THE SPONTANEOUS REGRESSION OF THE SHOPE RABBIT PAPILLOMA.

Authors:  J W KREIDER
Journal:  Cancer Res       Date:  1963-10       Impact factor: 12.701

2.  Antitumor immunity in the Shope papilloma-carcinoma complex of rabbits. I. Papilloma regression induced by homologous and autologous tissue vaccines.

Authors:  C A EVANS; L R GORMAN; Y ITO; R S WEISER
Journal:  J Natl Cancer Inst       Date:  1962-08       Impact factor: 13.506

3.  A vaccination procedure which increases the frequency of regressions of Shope papillomas of rabbits.

Authors:  C A EVANS; L R GORMAN; Y ITO; R S WEISER
Journal:  Nature       Date:  1962-01-20       Impact factor: 49.962

4.  Fine structure of the cottontail rabbit papillomavirus mRNAs expressed in the transplantable VX2 carcinoma.

Authors:  O Danos; E Georges; G Orth; M Yaniv
Journal:  J Virol       Date:  1985-03       Impact factor: 5.103

5.  Antitumor immunity in the Shope papilloma-carcinoma complex of rabbits. 3. Response to reinfection with viral nucleic acid.

Authors:  C A Evans; Y Ito
Journal:  J Natl Cancer Inst       Date:  1966-06       Impact factor: 13.506

6.  The open reading frame L2 of cottontail rabbit papillomavirus contains antibody-inducing neutralizing epitopes.

Authors:  N D Christensen; J W Kreider; N C Kan; S L DiAngelo
Journal:  Virology       Date:  1991-04       Impact factor: 3.616

7.  Cottontail rabbit papillomavirus L1 protein-based vaccines: protection is achieved only with a full-length, nondenatured product.

Authors:  Y L Lin; L A Borenstein; R Ahmed; F O Wettstein
Journal:  J Virol       Date:  1993-07       Impact factor: 5.103

8.  Antibody and cytotoxic T-cell responses to soluble hepatitis B virus (HBV) S antigen in mice: implication for the pathogenesis of HBV-induced hepatitis.

Authors:  R Schirmbeck; K Melber; T Mertens; J Reimann
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103

9.  Analysis of the nucleotide sequence variation of the antigen-binding domain of DR alpha and DQ alpha molecules as related to the evolution of papillomavirus-induced warts in rabbits.

Authors:  R Han; F Breitburd; P N Marche; G Orth
Journal:  J Invest Dermatol       Date:  1994-09       Impact factor: 8.551

10.  Progression from papilloma to carcinoma is accompanied by changes in antibody response to papillomavirus proteins.

Authors:  Y L Lin; L A Borenstein; R Selvakumar; R Ahmed; F O Wettstein
Journal:  J Virol       Date:  1993-01       Impact factor: 5.103
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  18 in total

1.  Recombinant Listeria monocytogenes vaccination eliminates papillomavirus-induced tumors and prevents papilloma formation from viral DNA.

Authors:  E R Jensen; R Selvakumar; H Shen; R Ahmed; F O Wettstein; J F Miller
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

Review 2.  The role of vaccines in the control of STDs: HPV vaccines.

Authors:  I H Frazer
Journal:  Genitourin Med       Date:  1996-12

3.  Regression of papillomas induced by cottontail rabbit papillomavirus is associated with infiltration of CD8+ cells and persistence of viral DNA after regression.

Authors:  R Selvakumar; A Schmitt; T Iftner; R Ahmed; F O Wettstein
Journal:  J Virol       Date:  1997-07       Impact factor: 5.103

4.  Using HLA-A2.1 Transgenic Rabbit Model to Screen and Characterize New HLA-A2.1 Restricted Epitope DNA Vaccines.

Authors:  Jiafen Hu; Todd D Schell; Xuwen Peng; Nancy M Cladel; Karla K Balogh; Neil D Christensen
Journal:  J Vaccines Vaccin       Date:  2010-08-20

5.  Combination treatment with intralesional cidofovir and viral-DNA vaccination cures large cottontail rabbit papillomavirus-induced papillomas and reduces recurrences.

Authors:  N D Christensen; R Han; N M Cladel; M D Pickel
Journal:  Antimicrob Agents Chemother       Date:  2001-04       Impact factor: 5.191

6.  Induction of the bovine papillomavirus origin "onion skin"-type DNA replication at high E1 protein concentrations in vivo.

Authors:  Andres Männik; Kertu Rünkorg; Nele Jaanson; Mart Ustav; Ene Ustav
Journal:  J Virol       Date:  2002-06       Impact factor: 5.103

Review 7.  The emergence of immunomodulation: combinatorial immunochemotherapy opportunities for the next decade.

Authors:  Lana E Kandalaft; Nathan Singh; John B Liao; Andrea Facciabene; Jonathan S Berek; Daniel J Powell; George Coukos
Journal:  Gynecol Oncol       Date:  2009-12-02       Impact factor: 5.482

8.  Vaccination of rabbits with an adenovirus vector expressing the papillomavirus E2 protein leads to clearance of papillomas and infection.

Authors:  Janet L Brandsma; Mark Shlyankevich; Lixin Zhang; Martin D Slade; Edward C Goodwin; Woei Peh; Albert B Deisseroth
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103

9.  Vesicular stomatitis virus-based therapeutic vaccination targeted to the E1, E2, E6, and E7 proteins of cottontail rabbit papillomavirus.

Authors:  Janet L Brandsma; Mark Shylankevich; Yuhua Su; Anjeanette Roberts; John K Rose; Daniel Zelterman; Linda Buonocore
Journal:  J Virol       Date:  2007-03-28       Impact factor: 5.103

10.  Intracutaneous DNA vaccination with the E8 gene of cottontail rabbit papillomavirus induces protective immunity against virus challenge in rabbits.

Authors:  Jiafen Hu; Ricai Han; Nancy M Cladel; Martin D Pickel; Neil D Christensen
Journal:  J Virol       Date:  2002-07       Impact factor: 5.103
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