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Literature DB >> 7983754

Retinoid X receptor alpha transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor.

Abstract

The hepatitis B virus enhancer 1 contains a retinoic acid responsive element (RARE). We have previously demonstrated that retinoid X receptor alpha (RXR alpha) transactivates enhancer 1 by binding to the RARE. The present study has revealed that a heterodimeric complex composed of RXR alpha and peroxisome proliferator-activated receptor (PPAR) interacts with the hepatitis B virus RARE. Transient transfection studies, in conjunction with in vitro DNA binding data, support the hypothesis that the RXR alpha-PPAR heterodimer transactivates enhancer 1.

Entities: Chemical Gene Species

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Year: 1995 PMID： 7983754 PMCID： PMC188608 DOI： 10.1128/JVI.69.1.547-551.1995

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

46 in total

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Journal: Genes Dev Date: 1992-03 Impact factor: 11.361

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Journal: Nature Date: 1992-01-30 Impact factor: 49.962

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Journal: EMBO J Date: 1992-02 Impact factor: 11.598

22 in total

1. Multiple parameters determine the specificity of transcriptional response by nuclear receptors HNF-4, ARP-1, PPAR, RAR and RXR through common response elements.

Authors: H Nakshatri; P Bhat-Nakshatri
Journal: Nucleic Acids Res Date: 1998-05-15 Impact factor: 16.971

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Authors: M Blake; J Niklinski; M Zajac-Kaye
Journal: J Virol Date: 1996-09 Impact factor: 5.103

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Authors: Yuchen Xia; Arnaud Carpentier; Xiaoming Cheng; Peter Daniel Block; Yao Zhao; Zhensheng Zhang; Ulrike Protzer; T Jake Liang
Journal: J Hepatol Date: 2016-10-14 Impact factor: 25.083

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Authors: X Yu; J E Mertz
Journal: J Virol Date: 2001-12 Impact factor: 5.103

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Journal: J Virol Date: 1997-12 Impact factor: 5.103