OBJECTIVE: This paper reports comprehensive data on psychiatric symptoms and disorders and medical problems of first- and second-degree biological relatives of prepubertal children who have contemplated or attempted suicide. METHOD: Standard family study and family history interview techniques were used to obtain information about psychopathology and medical illness in 488 first- and 1,062 second-degree relatives of 25 child psychiatric inpatients who reported suicide attempts, 28 child psychiatric inpatients who contemplated suicide, 16 nonsuicidal child inpatients, and 54 normal children. RESULTS: Suicidal behavior in children was associated with suicidal behavior in their families, although no first-degree relatives committed suicide. More first-degree relatives of child suicide attempters, compared to first-degree relatives of normal children, had antisocial personality disorder, assaultive behavior, and substance abuse. Mood disorders in first-degree relatives were not associated with child suicidal behavior. No significant associations were identified for psychopathology of second-degree relatives and child suicidal behavior. CONCLUSIONS: The results suggest the importance of evaluating familial psychopathology during assessments of suicidal children. Self-directed and externally directed violence, antisocial personality disorder, and substance abuse of relatives of suicidal children should be studied to elucidate the etiology of youth suicidal behavior.
OBJECTIVE: This paper reports comprehensive data on psychiatric symptoms and disorders and medical problems of first- and second-degree biological relatives of prepubertal children who have contemplated or attempted suicide. METHOD: Standard family study and family history interview techniques were used to obtain information about psychopathology and medical illness in 488 first- and 1,062 second-degree relatives of 25 childpsychiatric inpatients who reported suicide attempts, 28 childpsychiatric inpatients who contemplated suicide, 16 nonsuicidal child inpatients, and 54 normal children. RESULTS: Suicidal behavior in children was associated with suicidal behavior in their families, although no first-degree relatives committed suicide. More first-degree relatives of child suicide attempters, compared to first-degree relatives of normal children, had antisocial personality disorder, assaultive behavior, and substance abuse. Mood disorders in first-degree relatives were not associated with child suicidal behavior. No significant associations were identified for psychopathology of second-degree relatives and child suicidal behavior. CONCLUSIONS: The results suggest the importance of evaluating familial psychopathology during assessments of suicidal children. Self-directed and externally directed violence, antisocial personality disorder, and substance abuse of relatives of suicidal children should be studied to elucidate the etiology of youth suicidal behavior.
Authors: Beth S Brodsky; J John Mann; Barbara Stanley; Adrienne Tin; Maria Oquendo; Boris Birmaher; Laurence Greenhill; David Kolko; Jamie Zelazny; Ainsley Keller Burke; Nadine M Melhem; David Brent Journal: J Clin Psychiatry Date: 2008-04 Impact factor: 4.384
Authors: V L Willour; F Seifuddin; P B Mahon; D Jancic; M Pirooznia; J Steele; B Schweizer; F S Goes; F M Mondimore; D F Mackinnon; R H Perlis; P H Lee; J Huang; J R Kelsoe; P D Shilling; M Rietschel; M Nöthen; S Cichon; H Gurling; S Purcell; J W Smoller; N Craddock; J R DePaulo; T G Schulze; F J McMahon; P P Zandi; J B Potash Journal: Mol Psychiatry Date: 2011-03-22 Impact factor: 15.992
Authors: T D Gould; P Georgiou; L A Brenner; L Brundin; A Can; P Courtet; Z R Donaldson; Y Dwivedi; S Guillaume; I I Gottesman; S Kanekar; C A Lowry; P F Renshaw; D Rujescu; E G Smith; G Turecki; P Zanos; C A Zarate; P A Zunszain; T T Postolache Journal: Transl Psychiatry Date: 2017-04-11 Impact factor: 6.222