Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Somatostatin receptor subtype SSTR2 mediates the inhibition of high-voltage-activated calcium channels by somatostatin and its analogue SMS 201-995.

Literature DB >> 7982482

Somatostatin receptor subtype SSTR2 mediates the inhibition of high-voltage-activated calcium channels by somatostatin and its analogue SMS 201-995.

Y Fujii¹, T Gonoi, Y Yamada, K Chihara, N Inagaki, S Seino.

Abstract

Somatostatin and its analogue SMS 201-995 inhibit high voltage-activated (HVA) Ca2+ currents in the rat insulinoma cell line RINm5F which stably express cloned human somatostatin receptor subtype 2 (hSSTR2). In contrast, neither somatostatin nor SMS 201-995 suppresses the HVA Ca2+ currents in RINm5F which stably express cloned hSSTR1. These results suggest that somatostatin-induced inhibition of HVA Ca2+ currents is mediated by a specific receptor subtype and that inhibition of calcium influx through HVA Ca2+ channels is one of the mechanisms of SMS 201-995 action on inhibitory processes of hormone secretion and cell proliferation.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1994 PMID： 7982482 DOI： 10.1016/0014-5793(94)01159-1

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

Keyword Cloud
Cited

9 in total

1. Selective G-protein regulation of neuronal calcium channels.

Authors: P T Toth; L R Shekter; G H Ma; L H Philipson; R J Miller
Journal: J Neurosci Date: 1996-08-01 Impact factor: 6.167

Review 2. Molecular pharmacology of somatostatin receptor subtypes.

Authors: Y C Patel
Journal: J Endocrinol Invest Date: 1997-06 Impact factor: 4.256

3. Sulfonylurea receptor knockout causes glucose intolerance in mice that is not alleviated by concomitant somatostatin subtype receptor 5 knockout.

Authors: Michael Norman; Stefan Moldovan; Victor Seghers; Xiao-Ping Wang; Francesco J DeMayo; F Charles Brunicardi
Journal: Ann Surg Date: 2002-06 Impact factor: 12.969

4. Research Resource: Real-Time Analysis of Somatostatin and Dopamine Receptor Signaling in Pituitary Cells Using a Fluorescence-Based Membrane Potential Assay.

Authors: Thomas Günther; Michael Culler; Stefan Schulz
Journal: Mol Endocrinol Date: 2016-03-11

5. Somatostatin-Mediated Changes in Microtubule-Associated Proteins and Retinoic Acid-Induced Neurite Outgrowth in SH-SY5Y Cells.

Authors: Seungil Paik; Rishi K Somvanshi; Ujendra Kumar
Journal: J Mol Neurosci Date: 2019-03-16 Impact factor: 3.444

Somatostatin receptor subtype SSTR2 mediates the inhibition of high-voltage-activated calcium channels by somatostatin and its analogue SMS 201-995.

1. Selective G-protein regulation of neuronal calcium channels.

Review 2. Molecular pharmacology of somatostatin receptor subtypes.

3. Sulfonylurea receptor knockout causes glucose intolerance in mice that is not alleviated by concomitant somatostatin subtype receptor 5 knockout.

4. Research Resource: Real-Time Analysis of Somatostatin and Dopamine Receptor Signaling in Pituitary Cells Using a Fluorescence-Based Membrane Potential Assay.

5. Somatostatin-Mediated Changes in Microtubule-Associated Proteins and Retinoic Acid-Induced Neurite Outgrowth in SH-SY5Y Cells.

6. Comparative distribution of somatostatin and somatostatin receptors in PTU-induced hypothyroidism.

7. Primate cell fusion disentangles gene regulatory divergence in neurodevelopment.

Review 8. Somatostatin receptor biology in neuroendocrine and pituitary tumours: part 1--molecular pathways.

9. Peptide receptor targeting in cancer: the somatostatin paradigm.