Literature DB >> 7981973

The HIV-1 nef gene acts as a positive viral infectivity factor.

M D Miller1, M B Feinberg, W C Greene.   

Abstract

The gene product of the nef gene of HIV-1 acts both to increase the infectivity of viral particles and to reduce the expression of the CD4 receptor molecule on the cell surface. These two functions of Nef may be related, in that downregulation of CD4 may promote the production of HIV that has greater infectivity.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7981973     DOI： 10.1016/0966-842x(94)90007-8

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  21 in total

1.  Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require Nef for optimal infectivity.

Authors:  N Chazal; G Singer; C Aiken; M L Hammarskjöld; D Rekosh
Journal:  J Virol       Date:  2001-04       Impact factor: 5.103

2.  Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions.

Authors:  E Schaeffer; R Geleziunas; W C Greene
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

3.  Compensatory link between fusion and endocytosis of human immunodeficiency virus type 1 in human CD4 T lymphocytes.

Authors:  Evelyne Schaeffer; Vanessa B Soros; Warner C Greene
Journal:  J Virol       Date:  2004-02       Impact factor: 5.103

4.  Impaired Downregulation of NKG2D Ligands by Nef Proteins from Elite Controllers Sensitizes HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity.

Authors:  Nirmin Alsahafi; Jonathan Richard; Jérémie Prévost; Mathieu Coutu; Nathalie Brassard; Matthew S Parsons; Daniel E Kaufmann; Mark Brockman; Andrés Finzi
Journal:  J Virol       Date:  2017-07-27       Impact factor: 5.103

5.  Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell.

Authors:  O Schwartz; V Maréchal; O Danos; J M Heard
Journal:  J Virol       Date:  1995-07       Impact factor: 5.103

6.  Restoration of wild-type infectivity to human immunodeficiency virus type 1 strains lacking nef by intravirion reverse transcription.

Authors:  M Khan; M Garcia-Barrio; M D Powell
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

7.  Human immunodeficiency virus type 1 Nef-induced CD4 cell surface downregulation is inhibited by ikarugamycin.

Authors:  T Luo; B L Fredericksen; K Hasumi; A Endo; J V Garcia
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

8.  Characterization and molecular basis of the oligomeric structure of HIV-1 nef protein.

Authors:  S Arold; F Hoh; S Domergue; C Birck; M A Delsuc; M Jullien; C Dumas
Journal:  Protein Sci       Date:  2000-06       Impact factor: 6.725

9.  Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking.

Authors:  A Mangasarian; V Piguet; J K Wang; Y L Chen; D Trono
Journal:  J Virol       Date:  1999-03       Impact factor: 5.103

10.  Inhibition of Nef- and phorbol ester-induced CD4 degradation by macrolide antibiotics.

Authors:  T Luo; S J Anderson; J V Garcia
Journal:  J Virol       Date:  1996-03       Impact factor: 5.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.