Literature DB >> 7981152

IL-2 receptor alpha chain expression during early B lymphocyte differentiation.

J Chen1, A Ma, F Young, F W Alt.   

Abstract

The IL-2/IL-2 receptor (IL-2R) has been studied intensively because of its potential function in the development and regulation of the immune system. The IL-2R alpha chain has been shown to be expressed on CD4-CD8- thymocytes and activated T and B cells. In this report, we show that IL-2R alpha is also expressed on precursor B cells in the bone marrow. Its expression is initiated by functional rearrangement and expression of Ig mu heavy chain gene and is down-regulated when immature B cells mature and express IgD. Its potential function in early B cell differentiation is discussed in comparison with its role in thymocyte differentiation.

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Year:  1994        PMID： 7981152     DOI： 10.1093/intimm/6.8.1265

Source DB:  PubMed          Journal:  Int Immunol        ISSN： 0953-8178            Impact factor:   4.823


  14 in total

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4.  Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice.

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Authors:  Y Levy; K Benlagha; A Buzyn; M Colombel; J C Brouet; K Lassoued
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7.  Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop.

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8.  The transcription factor early growth response 1 (Egr-1) advances differentiation of pre-B and immature B cells.

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9.  Inhibition of interleukin 7 receptor signaling by antigen receptor assembly.

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10.  Demonstration of early functional compromise of bone marrow derived hematopoietic progenitor cells during bovine neonatal pancytopenia through in vitro culture of bone marrow biopsies.

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