Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Effects of E5a and E7 genes of human papillomavirus type 11 on immortalized human epidermal keratinocytes and NIH 3T3 cells.

Literature DB >> 7980008

Effects of E5a and E7 genes of human papillomavirus type 11 on immortalized human epidermal keratinocytes and NIH 3T3 cells.

Y P Tsao¹, T Y Chu, T M Chen, Y F Yang, S L Chen.

Abstract

The E5a gene of HPV-11 expressed in NIH 3T3 cells led to tumorigenesis in nude mice; whereas when expressed in keratinocytes, E5a induced anchorage independent growth, but was nontumorigenic in nude mice. The E7 gene of HPV-11 expressed NIH 3T3 cells led to tumors in nude mice and morphological transformation, but not anchorage independent growth. Keratinocytes expressing the E7 gene induced colony formation in soft agarose, but not tumorigenesis in nude mice. Comparison of transforming activities of HPV-11 E5a and E7 genes of HPV-11 showed that the efficiency of cell transformation by E7 was weaker than that of E5a.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1994 PMID： 7980008 DOI： 10.1007/BF01310049

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

24 in total

1. Transcription of the E6 and E7 genes of human papillomavirus type 6 in anogenital condylomata is restricted to undifferentiated cell layers of the epithelium.

Authors: T Iftner; M Oft; S Böhm; S P Wilczynski; H Pfister
Journal: J Virol Date: 1992-08 Impact factor: 5.103

2. Differential effects of human papillomavirus type 6, 16, and 18 DNAs on immortalization and transformation of human cervical epithelial cells.

Authors: G Pecoraro; D Morgan; V Defendi
Journal: Proc Natl Acad Sci U S A Date: 1989-01 Impact factor: 11.205

3. Human papillomavirus types 6 and 11 mRNAs from genital condylomata acuminata.

Authors: L T Chow; M Nasseri; S M Wolinsky; T R Broker
Journal: J Virol Date: 1987-08 Impact factor: 5.103

4. Transforming activity of E5a protein of human papillomavirus type 6 in NIH 3T3 and C127 cells.

Authors: S L Chen; P Mounts
Journal: J Virol Date: 1990-07 Impact factor: 5.103

5. In vitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential.

Authors: M S Barbosa; W C Vass; D R Lowy; J T Schiller
Journal: J Virol Date: 1991-01 Impact factor: 5.103

6. Identification and typing of human papillomavirus in cervical cancers in Taiwan.

Authors: S L Chen; C P Han; Y P Tsao; J W Lee; C S Yin
Journal: Cancer Date: 1993-09-15 Impact factor: 6.860

7. Comparative study on E6 and E7 genes of some cutaneous and genital papillomaviruses of human origin for their ability to transform 3Y1 cells.

Authors: A Hiraiwa; T Kiyono; K Segawa; K R Utsumi; M Ohashi; M Ishibashi
Journal: Virology Date: 1993-01 Impact factor: 3.616

8. Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16.

Authors: C Leptak; S Ramon y Cajal; R Kulke; B H Horwitz; D J Riese; G P Dotto; D DiMaio
Journal: J Virol Date: 1991-12 Impact factor: 5.103

9. E5a gene of human papillomavirus type 11 is required for initiation but not for maintenance of transformation in NIH 3T3 cells.

Authors: S L Chen; Y P Tsao; J W Lee; H S Liu; C M Yang; L T Tsao
Journal: J Gen Virol Date: 1994-08 Impact factor: 3.891

10. The E5 gene from human papillomavirus type 16 is an oncogene which enhances growth factor-mediated signal transduction to the nucleus.

Authors: P Leechanachai; L Banks; F Moreau; G Matlashewski
Journal: Oncogene Date: 1992-01 Impact factor: 9.867

4 in total

1. Human papillomavirus type 11 and 16 E5 represses p21(WafI/SdiI/CipI) gene expression in fibroblasts and keratinocytes.

Authors: Y P Tsao; L Y Li; T C Tsai; S L Chen
Journal: J Virol Date: 1996-11 Impact factor: 5.103