| Literature DB >> 7979830 |
M S Santos1, F Ferreira, A P Cunha, A P Carvalho, C F Ribeiro, T Macedo.
Abstract
The effect of an aqueous extract obtained from the roots of Valeriana officinalis was investigated on the uptake and release of GABA in synaptosomes isolated from rat brain cortex. Aqueous extract of valerian inhibited the uptake and stimulated the release of [3H]GABA, either in the absence or in the presence of K+ depolarization. The release was Na(+)-dependent and independent of the presence of Ca2+ in the external medium. It is concluded that valerian extract releases [3H]GABA by reversal of the GABA carrier, which is Na(+)-dependent and Ca(2+)-independent. This increase in [3H]GABA release appears to be independent from Na(+)-K(+)-ATPase activity and the membrane potential.Entities:
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Year: 1994 PMID： 7979830
Source DB: PubMed Journal: Arch Int Pharmacodyn Ther ISSN： 0003-9780