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Literature DB >> 7979298

Macrolide antibiotics protect against endotoxin-induced vascular leakage and neutrophil accumulation in rat trachea.

Abstract

We studied the effects of macrolides on lipopolysaccharide (LPS)-induced airway inflammation in the rat tracheal mucosa. Erythromycin and roxithromycin dose dependently inhibited microvascular leakage and neutrophil recruitment induced by LPS. This inhibitory action on vascular permeability was abolished by neutrophil depletion.

Entities: Chemical Disease Species

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Year: 1994 PMID： 7979298 PMCID： PMC284605 DOI： 10.1128/AAC.38.7.1641

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

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9 in total

1. Direct evidence for antipseudomonal activity of macrolides: exposure-dependent bactericidal activity and inhibition of protein synthesis by erythromycin, clarithromycin, and azithromycin.

Authors: K Tateda; Y Ishii; T Matsumoto; N Furuya; M Nagashima; T Matsunaga; A Ohno; S Miyazaki; K Yamaguchi
Journal: Antimicrob Agents Chemother Date: 1996-10 Impact factor: 5.191

Review 2. The Role of Macrolides in Chronic Rhinosinusitis (CRSsNP and CRSwNP).

Authors: Gretchen M Oakley; Richard J Harvey; Valerie J Lund
Journal: Curr Allergy Asthma Rep Date: 2017-05 Impact factor: 4.806

3. Efficacy of concomitant administration of clarithromycin and acetylcysteine in bronchiolitis obliterans in seventeen sulfur mustard-exposed patients: An open-label study.

Authors: Mostafa Ghanei; Kamran Abolmaali; Jafar Aslani
Journal: Curr Ther Res Clin Exp Date: 2004-11

4. Tilmicosin induces apoptosis in bovine peripheral neutrophils in the presence or in the absence of Pasteurella haemolytica and promotes neutrophil phagocytosis by macrophages.

Authors: A C Chin; W D Lee; K A Murrin; D W Morck; J K Merrill; P Dick; A G Buret
Journal: Antimicrob Agents Chemother Date: 2000-09 Impact factor: 5.191

5. Cefiderocol Protects against Cytokine- and Endotoxin-Induced Disruption of Vascular Endothelial Cell Integrity in an In Vitro Experimental Model.

Authors: Dagmar Hildebrand; Jana Böhringer; Eva Körner; Ute Chiriac; Sandra Förmer; Aline Sähr; Torsten Hoppe-Tichy; Klaus Heeg; Dennis Nurjadi
Journal: Antibiotics (Basel) Date: 2022-04-26