Literature DB >> 7976377

Scavenging effects of tetramethylpyrazine on active oxygen free radicals.

Z H Zhang1, S Z Yu, Z T Wang, B L Zhao, J W Hou, F J Yang, W J Xin.   

Abstract

The scavenging effects of tetramethylpyrazine (ligustrazine, Lig) isolated from Ligusticum wallichii Franch on active oxygen free radicals were studied using spin trapping technic and chemiluminescence methods. The scavenging rate of superoxide anion (O2-.) by Lig (25 mg.ml-1) was 100% in xanthine/xanthine oxidase (Xan/XO) system, and that of hydroxyl radical (OH-.) was 44% in Fenton's reaction. The scavenging rate of lipid peroxyl radical (LOO-.) by Lig (25 mg.ml-1) was 80% in peroxidizing microsome system. It is possible that Lig scavenged O2-. by catalyzing its spontaneous dismutation. The results showed that Lig had strong effects of scavenging cyotoxic oxygen free radicals (O2-., LOO-., OH-.).

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Year:  1994        PMID： 7976377

Source DB:  PubMed          Journal:  Zhongguo Yao Li Xue Bao        ISSN： 0253-9756


  13 in total

1.  Effects of tetramethylpyrazine on the release of PGI2 and TXA2 in the hypoxic isolated rat heart.

Authors:  J Feng; R Liu; G Wu; S Tang
Journal:  Mol Cell Biochem       Date:  1997-02       Impact factor: 3.396

2.  Ligustrazine-induced endothelium-dependent relaxation in pulmonary arteries via an NO-mediated and exogenous L-arginine-dependent mechanism.

Authors:  W Peng; D Hucks; R M Priest; Y M Kan; J P Ward
Journal:  Br J Pharmacol       Date:  1996-11       Impact factor: 8.739

3.  Effects of tetramethylpyrazine phosphate on pancreatic islet microcirculation in SD rats.

Authors:  X Xu; L Wu; Z Q Lu; P Xia; X P Zhu; X Gao
Journal:  J Endocrinol Invest       Date:  2017-09-16       Impact factor: 4.256

4.  Preventive effect of tetramethylpyrazine on intestinal mucosal injury in rats with acute necrotizing pancreatitis.

Authors:  Jian-Xin Zhang; Sheng-Chun Dang; Jian-Guo Qu; Xue-Qing Wang
Journal:  World J Gastroenterol       Date:  2006-10-21       Impact factor: 5.742

5.  Anti-apoptotic and neuroprotective effects of Tetramethylpyrazine following spinal cord ischemia in rabbits.

Authors:  Li-Hong Fan; Kun-Zheng Wang; Bin Cheng; Chun-Sheng Wang; Xiao-Qian Dang
Journal:  BMC Neurosci       Date:  2006-06-14       Impact factor: 3.288

6.  Tetramethylpyrazine attenuates spinal cord ischemic injury due to aortic cross-clamping in rabbits.

Authors:  Shaoyang Chen; Lize Xiong; Qiang Wang; Hanfei Sang; Zhenhua Zhu; Hailong Dong; Zhihong Lu
Journal:  BMC Neurol       Date:  2002-04-17       Impact factor: 2.474

7.  Buyang Huanwu decoction enhances cell membrane fluidity in rats with cerebral ischemia/reperfusion.

Authors:  Chenxu Li
Journal:  Neural Regen Res       Date:  2012-07-25       Impact factor: 5.135

8.  Neural protection by naturopathic compounds-an example of tetramethylpyrazine from retina to brain.

Authors:  Zhiqun Tan
Journal:  J Ocul Biol Dis Infor       Date:  2009-07-14

9.  Erratum: Neural protection by naturopathic compounds-an example of tetramethylpyrazine from retina to brain.

Authors:  Zhiqun Tan
Journal:  J Ocul Biol Dis Infor       Date:  2009-09-01

10.  Nephroprotective Effects of Tetramethylpyrazine Nitrone TBN in Diabetic Kidney Disease.

Authors:  Mei Jing; Yun Cen; Fangfang Gao; Ting Wang; Jinxin Jiang; Qianqian Jian; Liangmiao Wu; Baojian Guo; Fangcheng Luo; Gaoxiao Zhang; Ying Wang; Lipeng Xu; Zaijun Zhang; Yewei Sun; Yuqiang Wang
Journal:  Front Pharmacol       Date:  2021-06-24       Impact factor: 5.810
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