Literature DB >> 7975855

Increased encapsulation and virulence of Francisella tularensis live vaccine strain (LVS) by subculturing on synthetic medium.

J W Cherwonogrodzky1, M H Knodel, M R Spence.   

Abstract

Francisella tularensis live vaccine strain (LVS), taken directly from lyophilized vials, did not appear to have a capsule and had low virulence for Balb/c mice. When this strain was subcultured on Chamberlain's synthetic medium (pH 6.5), it became extensively capsulated (1-5 micron in diameter) and its virulence for Balb/c mice increased about 1000-fold. We conclude that the virulence of the attenuated vaccine strain, F. tularensis LVS, may still be influenced by growth conditions.

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Year:  1994        PMID： 7975855     DOI： 10.1016/0264-410x(94)90284-4

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  26 in total

1.  Francisella tularensis Schu S4 O-antigen and capsule biosynthesis gene mutants induce early cell death in human macrophages.

Authors:  Stephen R Lindemann; Kaitian Peng; Matthew E Long; Jason R Hunt; Michael A Apicella; Denise M Monack; Lee-Ann H Allen; Bradley D Jones
Journal:  Infect Immun       Date:  2010-11-15       Impact factor: 3.441

2.  Role of the wbt locus of Francisella tularensis in lipopolysaccharide O-antigen biogenesis and pathogenicity.

Authors:  Catherine Raynaud; Karin L Meibom; Marie-Annick Lety; Iharilalao Dubail; Thomas Candela; Eric Frapy; Alain Charbit
Journal:  Infect Immun       Date:  2006-10-09       Impact factor: 3.441

3.  Differential infection of mononuclear phagocytes by Francisella tularensis: role of the macrophage mannose receptor.

Authors:  Grant S Schulert; Lee-Ann H Allen
Journal:  J Leukoc Biol       Date:  2006-06-30       Impact factor: 4.962

Review 4.  The Francisella tularensis Polysaccharides: What Is the Real Capsule?

Authors:  Kelly C Freudenberger Catanzaro; Thomas J Inzana
Journal:  Microbiol Mol Biol Rev       Date:  2020-02-12       Impact factor: 11.056

5.  Identification of differentially regulated francisella tularensis genes by use of a newly developed Tn5-based transposon delivery system.

Authors:  Blake W Buchan; Molly K McLendon; Bradley D Jones
Journal:  Appl Environ Microbiol       Date:  2008-03-14       Impact factor: 4.792

6.  Identification, characterization and immunogenicity of an O-antigen capsular polysaccharide of Francisella tularensis.

Authors:  Michael A Apicella; Deborah M B Post; Andrew C Fowler; Bradley D Jones; Jed A Rasmussen; Jason R Hunt; Sayaka Imagawa; Biswa Choudhury; Thomas J Inzana; Tamara M Maier; Dara W Frank; Thomas C Zahrt; Kathryn Chaloner; Michael P Jennings; Molly K McLendon; Bradford W Gibson
Journal:  PLoS One       Date:  2010-07-06       Impact factor: 3.240

7.  FeoB-mediated uptake of iron by Francisella tularensis.

Authors:  Cindy A Thomas-Charles; Huaixin Zheng; Lance E Palmer; Patricio Mena; David G Thanassi; Martha B Furie
Journal:  Infect Immun       Date:  2013-05-28       Impact factor: 3.441

8.  Presence of pili on the surface of Francisella tularensis.

Authors:  Horacio Gil; Jorge L Benach; David G Thanassi
Journal:  Infect Immun       Date:  2004-05       Impact factor: 3.441

9.  Epitope-based vaccination against pneumonic tularemia.

Authors:  Stephen H Gregory; Stephanie Mott; Jennifer Phung; Jinhee Lee; Leonard Moise; Julie A McMurry; William Martin; Anne S De Groot
Journal:  Vaccine       Date:  2009-07-17       Impact factor: 3.641

10.  The role of complement opsonization in interactions between F. tularensis subsp. novicida and human neutrophils.

Authors:  Jason H Barker; Ramona L McCaffrey; Nicki K Baman; Lee-Ann H Allen; Jerrold P Weiss; William M Nauseef
Journal:  Microbes Infect       Date:  2009-05-04       Impact factor: 2.700
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