Literature DB >> 7975248

2-LTR circular viral DNA as a marker for human immunodeficiency virus type 1 infection in vivo.

C D Pauza1, P Trivedi, T S McKechnie, D D Richman, F M Graziano.   

Abstract

The unintegrated viral DNA found in human immunodeficiency virus type 1 infection includes linear and circular forms. We targeted the circular form containing two copies of the viral long terminal repeat (2-LTR circle) and developed specific assays to detect this molecule in peripheral blood mononuclear cells from HIV-infected patients. In vitro HIV-1 infection of peripheral blood mononuclear cells showed rapid accumulation and rapid decay of 2-LTR circular viral DNA. Examination of 2-LTR circular viral DNA levels provides a view of spreading infection based on a viral DNA form that is structurally distinct and has a known, short half-life in infected cells. In patients not receiving antiviral therapy, the levels of 2-LTR circular viral DNA and total viral DNA were significantly correlated to CD4 cell counts. Similar correlations were not observed in patients receiving zidovudine (AZT), didanosine (ddA), or zalcitabine (ddC).

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Year:  1994        PMID： 7975248     DOI： 10.1006/viro.1994.1667

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  40 in total

1.  Nonintegrated circular forms of the HIV-1 provirus DNA in experimental HIV infection.

Authors:  N M Gashnikova; O A Plyasunova; O A Mamaeva; N V Fedyuk; A G Pokrovskii
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2.  Zinc finger protein designed to target 2-long terminal repeat junctions interferes with human immunodeficiency virus integration.

Authors:  Supachai Sakkhachornphop; Carlos F Barbas; Rassamee Keawvichit; Kanlaya Wongworapat; Chatchai Tayapiwatana
Journal:  Hum Gene Ther       Date:  2012-05-08       Impact factor: 5.695

3.  New tools to track HIV.

Authors:  Timothy Schacker
Journal:  Nat Med       Date:  2010-04       Impact factor: 53.440

4.  Specific recognition and cleavage of the plus-strand primer by reverse transcriptase.

Authors:  Angela Atwood-Moore; Kenechi Ejebe; Henry L Levin
Journal:  J Virol       Date:  2005-12       Impact factor: 5.103

5.  Decay of human immunodeficiency virus type 1 unintegrated DNA containing two long terminal repeats in infected individuals after 3 to 8 years of sustained control of viremia.

Authors:  Jennifer L McDermott; Isabella Martini; Davide Ferrari; Francesca Bertolotti; Claudio Giacomazzi; Giuseppe Murdaca; Francesco Puppo; Francesco Indiveri; Oliviero E Varnier
Journal:  J Clin Microbiol       Date:  2005-10       Impact factor: 5.948

6.  Persistent transcription of a nonintegrating mutant of simian immunodeficiency virus in rhesus macrophages.

Authors:  Yanfang Zheng; Ilnour Ourmanov; Vanessa M Hirsch
Journal:  Virology       Date:  2007-12-03       Impact factor: 3.616

7.  An HIV-1 replication pathway utilizing reverse transcription products that fail to integrate.

Authors:  Benjamin Trinité; Eric C Ohlson; Igor Voznesensky; Shashank P Rana; Chi N Chan; Saurabh Mahajan; Jason Alster; Sean A Burke; Dominik Wodarz; David N Levy
Journal:  J Virol       Date:  2013-09-18       Impact factor: 5.103

8.  Impact of Y143 HIV-1 integrase mutations on resistance to raltegravir in vitro and in vivo.

Authors:  Olivier Delelis; Sylvain Thierry; Frédéric Subra; Françoise Simon; Isabelle Malet; Chakib Alloui; Sophie Sayon; Vincent Calvez; Eric Deprez; Anne-Geneviève Marcelin; Luba Tchertanov; Jean-François Mouscadet
Journal:  Antimicrob Agents Chemother       Date:  2009-11-09       Impact factor: 5.191

9.  Intrinsic stability of episomal circles formed during human immunodeficiency virus type 1 replication.

Authors:  Theodore C Pierson; Tara L Kieffer; Christian T Ruff; Christopher Buck; Stephen J Gange; Robert F Siliciano
Journal:  J Virol       Date:  2002-04       Impact factor: 5.103

10.  Cellular microvesicle pathways can be targeted to transfer genetic information between non-immune cells.

Authors:  Amy M Skinner; S Lee O'Neill; Peter Kurre
Journal:  PLoS One       Date:  2009-07-13       Impact factor: 3.240
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