Literature DB >> 7974680

Genetic evidence that RI chloroquine resistance of Plasmodium falciparum is caused by recrudescence of resistant parasites.

H Babiker1, L Ranford-Cartwright, A Sultan, G Satti, D Walliker.   

Abstract

Isolates of Plasmodium falciparum from patients in a Sudanese village exhibiting RI resistance to chloroquine have been typed for allelic variants of 2 merozoite surface antigens, MSP1 and MSP2. Blood forms were taken from each patient before chloroquine was administered, and after parasites had reappeared following treatment. Each patient was found to be infected with genetically different parasites. However, in each patient the parasites of the recrudescent infections possessed the same alleles of each gene as those of the primary infection. The results show that the parasites which reappeared after chloroquine were a genuine recrudescence of the primary forms, and not derived from a new infection.

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Year:  1994        PMID： 7974680     DOI： 10.1016/0035-9203(94)90103-1

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  7 in total

1.  Effects of Plasmodium falciparum mixed infections on in vitro antimalarial drug tests and genotyping.

Authors:  Shengfa Liu; Jianbing Mu; Hongying Jiang; Xin-zhuan Su
Journal:  Am J Trop Med Hyg       Date:  2008-08       Impact factor: 2.345

2.  Only viable parasites are detected by PCR following clearance of rodent malarial infections by drug treatment or immune responses.

Authors:  W Jarra; G Snounou
Journal:  Infect Immun       Date:  1998-08       Impact factor: 3.441

3.  Plasmodium falciparum msp1 and msp2 genetic diversity and allele frequencies in parasites isolated from symptomatic malaria patients in Bobo-Dioulasso, Burkina Faso.

Authors:  Anyirékun Fabrice Somé; Thomas Bazié; Issaka Zongo; R Serge Yerbanga; Frédéric Nikiéma; Cathérine Neya; Liz Karen Taho; Jean-Bosco Ouédraogo
Journal:  Parasit Vectors       Date:  2018-05-30       Impact factor: 3.876

4.  Baseline malaria prevalence at the targeted pre-elimination districts in Ethiopia.

Authors:  Desalegn Nega; Adugna Abera; Bokretsion Gidey; Sindew Mekasha; Abnet Abebe; Dereje Dillu; Degu Mehari; Gudissa Assefa; Samuel Hailu; Mebrahatom Haile; Kebede Etana; Hiwot Solomon; Gezahagn Tesfaye; Daniel Nigatu; Zelalem Destaw; Berhane Tesfaye; Belendia Serda; Asnakew Yeshiwondim; Assefaw Getachew; Hiwot Teka; Honelegn Nahusenay; Semira Abdelmenan; Hailemariam Reda; Worku Bekele; Ayele Zewdie; Getachew Tollera; Ashenafi Assefa; Geremew Tasew; Adugna Woyessa; Ebba Abate
Journal:  BMC Public Health       Date:  2021-11-03       Impact factor: 3.295

5.  Optimization and validation of multi-coloured capillary electrophoresis for genotyping of Plasmodium falciparum merozoite surface proteins (msp1 and 2).

Authors:  Anne Liljander; Lisa Wiklund; Nicole Falk; Margaret Kweku; Andreas Mårtensson; Ingrid Felger; Anna Färnert
Journal:  Malar J       Date:  2009-04-23       Impact factor: 2.979

6.  Transmission of malaria and genotypic variability of Plasmodium falciparum on the island of Annobon (Equatorial Guinea).

Authors:  Jorge Cano; Pedro Berzosa; Aida de Lucio; Miguel Angel Descalzo; Leonardo Bobuakasi; Sisinio Nzambo; Melchor Ondo; Jesus N Buatiche; Gloria Nseng; Agustin Benito
Journal:  Malar J       Date:  2007-10-25       Impact factor: 2.979

7.  Comparative Analysis of Plasmodium falciparum Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing.

Authors:  Mariko Kanai; Tomas Yeo; Victor Asua; Philip J Rosenthal; David A Fidock; Sachel Mok
Journal:  Antimicrob Agents Chemother       Date:  2021-10-25       Impact factor: 5.191
  7 in total

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