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Literature DB >> 797389

Peptidyltransferase activity of ribosomes and a ribosome precursor from a mutant of Escherichia coli.

Abstract

Escherichia coli strain 15-28 is a mutant with a defect in ribosome synthesis that caused the accumulation of ribonucleoprotein ('47S') particles during exponential growth. These particles are precursors to 50S ribosomes that lack three ribosomal proteins. Peptidyltransferase activity and binding at the peptidyl site of the peptidyltransferase centre are greatly decreased in 47S particles. Both these activities are lower in the 50S and 70S ribosomes of strain 15-28 than in its parent. Unusual assembly of the larger ribosomal subunit in strain 15-28 may produce completed ribosomes with diminished biological activity.

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Year: 1976 PMID： 797389 PMCID： PMC1164291 DOI： 10.1042/bj1600721

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

23 in total

1. Substrate and antibiotic binding sites at the peptidyl transferase centre of E. coli ribosomes: Binding of UACCA-Leu to 50 S subunits.

Authors: M L. Celma; R E. Monro; D Vazquez
Journal: FEBS Lett Date: 1971-03-16 Impact factor: 4.124

10. Inhibition of bacterial growth by metal salts. The accumulation of ribonucleic acid during inhibition of Escherichia coli by cobalt chloride.

Authors: M R Blundell; D G Wild
Journal: Biochem J Date: 1969-11 Impact factor: 3.857

5 in total

1. Abnormal ribosome assembly in a mutant of Escherichia coli.

Authors: P D Butler; P F Sims; D G Wild
Journal: Biochem J Date: 1979-08-15 Impact factor: 3.857

2. Binding of chloramphenicol and a fragment of aminoacyl-transfer ribonucleic acid to ribosomes and a ribosome precursor from a mutant of Escherichia coli.

Authors: P D Butler; P F Sims; D G Wild
Journal: Biochem J Date: 1978-06-15 Impact factor: 3.857

Peptidyltransferase activity of ribosomes and a ribosome precursor from a mutant of Escherichia coli.

1. Substrate and antibiotic binding sites at the peptidyl transferase centre of E. coli ribosomes: Binding of UACCA-Leu to 50 S subunits.

2. Substrate and antibiotic binding sites at the peptidyl transferase centre of E. coli ribosomes.

3. An unusual precursor of 50S ribosomes in a mutant of Escherichia coli.

4. A protein involved in the peptidyltransferase activity of Escherichia coli ribosomes.

5. Ribosomal proteins. 43. In vivo assembly of Escherichia coli ribosomal proteins.

6. Investigation of the ribosomal peptidyl transferase center using a photoaffinity label.

7. Approaches to the genetics of Escherichia coli ribosomes.

8. On the catalytic center of peptidyl transfer: a part of the 50 S ribosome structure.

9. Identification of the chloramphenicol-binding protein in Escherichia coli ribosomes by partial reconstitution.

10. Inhibition of bacterial growth by metal salts. The accumulation of ribonucleic acid during inhibition of Escherichia coli by cobalt chloride.

1. Abnormal ribosome assembly in a mutant of Escherichia coli.

2. Binding of chloramphenicol and a fragment of aminoacyl-transfer ribonucleic acid to ribosomes and a ribosome precursor from a mutant of Escherichia coli.

3. Intermediates in the assembly of ribosomes by a mutant of Escherichia coli.

4. Mutations in the rpmBG operon of Escherichia coli that affect ribosome assembly.

5. Rpl33, a nonessential plastid-encoded ribosomal protein in tobacco, is required under cold stress conditions.