| Literature DB >> 7973727 |
M L Smith1, I T Chen, Q Zhan, I Bae, C Y Chen, T M Gilmer, M B Kastan, P M O'Connor, A J Fornace.
Abstract
GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.Entities:
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Year: 1994 PMID： 7973727 DOI： 10.1126/science.7973727
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728