Literature DB >> 7973660

A potential noninvasive neurobiological test for Alzheimer's disease.

L F Scinto1, K R Daffner, D Dressler, B I Ransil, D Rentz, S Weintraub, M Mesulam, H Potter.   

Abstract

Currently Alzheimer's disease, which affects more than 20 million people worldwide, can only be definitely diagnosed by histological examination of brain tissue obtained at autopsy or biopsy. There is a great need for an early, noninvasive, sensitive, and easily administered diagnostic test of Alzheimer's disease. Here it is reported that patients diagnosed with probable Alzheimer's disease by standard clinical criteria exhibited a marked hypersensitivity in their pupil dilation response to a cholinergic antagonist, tropicamide, placed in their eyes. It was possible to distinguish 18 of 19 individuals (95%) either clinically diagnosed with Alzheimer's disease or classified as suspect Alzheimer's individuals by neuropsychological screening from 30 of 32 normal elderly controls (94%).

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Year:  1994        PMID： 7973660     DOI： 10.1126/science.7973660

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  30 in total

1.  Probing peripheral and central cholinergic system responses.

Authors:  C A Naranjo; J Fourie; N Herrmann; K L Lanctôt; C Birt; K K Yau
Journal:  J Psychiatry Neurosci       Date:  2000-09       Impact factor: 6.186

Review 2.  Nonneurotropic adenovirus: a vector for gene transfer to the brain and gene therapy of neurological disorders.

Authors:  Pedro R Lowenstein; Donata Suwelack; Jinwei Hu; Xianpeng Yuan; Maximiliano Jimenez-Dalmaroni; Shyam Goverdhana; Maria G Castro
Journal:  Int Rev Neurobiol       Date:  2003       Impact factor: 3.230

3.  Why patients with Alzheimer's disease may show increased sensitivity to tropicamide eye drops: role of locus coeruleus.

Authors:  R H Hou; E R Samuels; M Raisi; R W Langley; E Szabadi; C M Bradshaw
Journal:  Psychopharmacology (Berl)       Date:  2005-11-25       Impact factor: 4.530

Review 4.  Eye movements in Alzheimer's disease.

Authors:  Robert J Molitor; Philip C Ko; Brandon A Ally
Journal:  J Alzheimers Dis       Date:  2015       Impact factor: 4.472

5.  Altered pupillary size and darkness and light reflexes in Alzheimer's disease.

Authors:  R Prettyman; P Bitsios; E Szabadi
Journal:  J Neurol Neurosurg Psychiatry       Date:  1997-06       Impact factor: 10.154

Review 6.  Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology.

Authors:  Harald Hampel; Nicola Toschi; Claudio Babiloni; Filippo Baldacci; Keith L Black; Arun L W Bokde; René S Bun; Francesco Cacciola; Enrica Cavedo; Patrizia A Chiesa; Olivier Colliot; Cristina-Maria Coman; Bruno Dubois; Andrea Duggento; Stanley Durrleman; Maria-Teresa Ferretti; Nathalie George; Remy Genthon; Marie-Odile Habert; Karl Herholz; Yosef Koronyo; Maya Koronyo-Hamaoui; Foudil Lamari; Todd Langevin; Stéphane Lehéricy; Jean Lorenceau; Christian Neri; Robert Nisticò; Francis Nyasse-Messene; Craig Ritchie; Simone Rossi; Emiliano Santarnecchi; Olaf Sporns; Steven R Verdooner; Andrea Vergallo; Nicolas Villain; Erfan Younesi; Francesco Garaci; Simone Lista
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472

7.  Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease.

Authors:  Markus Morawski; Maike Hartlage-Rübsamen; Carsten Jäger; Alexander Waniek; Stephan Schilling; Claudia Schwab; Patrick L McGeer; Thomas Arendt; Hans-Ulrich Demuth; Steffen Rossner
Journal:  Acta Neuropathol       Date:  2010-04-10       Impact factor: 17.088

8.  Pupillary dilatation test and Fourier analysis of pupillary oscillations in patients with multiple sclerosis.

Authors:  J Grünberger; L Linzmayer; E M Majda; A Reitner; H Walter
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1996       Impact factor: 5.270

9.  Pupil response biomarkers distinguish amyloid precursor protein mutation carriers from non-carriers.

Authors:  Shaun M Frost; Yogesan Kanagasingam; Hamid R Sohrabi; Kevin Taddei; Randall Bateman; John Morris; Tammie Benzinger; Alison Goate; Colin L Masters; Ralph N Martins
Journal:  Curr Alzheimer Res       Date:  2013-10       Impact factor: 3.498

10.  Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part II: physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans.

Authors:  E R Samuels; E Szabadi
Journal:  Curr Neuropharmacol       Date:  2008-09       Impact factor: 7.363
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