BACKGROUND: Data on risk factors for bone loss in chronic active hepatitis (CAH) and primary biliary cirrhosis (PBC) are scanty and/or conflicting. METHODS: Bone mineral density (BMD) in the distal forearm was measured using single-photon absorptiometry in 39 patients with CAH and 32 patients with PBC. We also attempted to identify risk factors for bone loss by means of a questionnaire and through a wide range of biochemical analyses. RESULTS: In the CAH patients BMD is inversely related to the duration of steroid treatment and to age at menarche. In the PBC patients there was a strong correlation between BMD and serum gastrin concentrations. CONCLUSIONS: Bone loss in CAH is to some extent explained by steroid treatment and delayed menarche. Bone loss in PBC may be reduced by increased calcitonin secretion induced by gastrocalcin.
BACKGROUND: Data on risk factors for bone loss in chronic active hepatitis (CAH) and primary biliary cirrhosis (PBC) are scanty and/or conflicting. METHODS: Bone mineral density (BMD) in the distal forearm was measured using single-photon absorptiometry in 39 patients with CAH and 32 patients with PBC. We also attempted to identify risk factors for bone loss by means of a questionnaire and through a wide range of biochemical analyses. RESULTS: In the CAH patientsBMD is inversely related to the duration of steroid treatment and to age at menarche. In the PBC patients there was a strong correlation between BMD and serum gastrin concentrations. CONCLUSIONS: Bone loss in CAH is to some extent explained by steroid treatment and delayed menarche. Bone loss in PBC may be reduced by increased calcitonin secretion induced by gastrocalcin.
Authors: D D Byrne; C W Newcomb; D M Carbonari; M S Nezamzadeh; K B F Leidl; M Herlim; Y X Yang; S Hennessy; J R Kostman; M B Leonard; A R Localio; V Lo Re Journal: J Viral Hepat Date: 2015-03-06 Impact factor: 3.728
Authors: Jerzy Konstantynowicz; Dariusz M Lebensztejn; Elzbieta Skiba; Maria E Sobaniec-Lotowska; Pawel Abramowicz; Janina Piotrowska-Jastrzebska; Maciej Kaczmarski Journal: J Bone Miner Metab Date: 2010-09-14 Impact factor: 2.626
Authors: Dana D Byrne; Craig W Newcomb; Dena M Carbonari; Melissa S Nezamzadeh; Kimberly B F Leidl; Maximilian Herlim; Yu-Xiao Yang; Sean Hennessy; Jay R Kostman; Mary B Leonard; A Russell Localio; Vincent Lo Re Journal: J Hepatol Date: 2014-04-05 Impact factor: 25.083