Literature DB >> 7972951

Measures of compounding conservatism in probabilistic risk assessment.

A C Cullen1.   

Abstract

Concern about the degree of uncertainty and potential conservatism in deterministic point estimates of risk has prompted researchers to turn increasingly to probabilistic methods for risk assessment. With Monte Carlo simulation techniques, distributions of risk reflecting uncertainty and/or variability are generated as an alternative. In this paper the compounding of conservatism between the level associated with point estimate inputs selected from probability distributions and the level associated with the deterministic value of risk calculated using these inputs is explored. Two measures of compounded conservatism are compared and contrasted. The first measure considered, F, is defined as the ratio of the risk value, Rd, calculated deterministically as a function of n inputs each at the jth percentile of its probability distribution, and the risk value, Rj, that falls at the jth percentile of the simulated risk distribution (i.e., F = Rd/Rj). The percentile of the simulated risk distribution which corresponds to the deterministic value, Rd, serves as a second measure of compounded conservatism. Analytical results for simple products of lognormal distributions are presented. In addition, a numerical treatment of several complex cases is presented using five simulation analyses from the literature to illustrate. Overall, there are cases in which conservatism compounds dramatically for deterministic point estimates of risk constructed from upper percentiles of input parameters, as well as those for which the effect is less notable. The analytical and numerical techniques discussed are intended to help analysts explore the factors that influence the magnitude of compounding conservation in specific cases.

Mesh:

Year:  1994        PMID: 7972951     DOI: 10.1111/j.1539-6924.1994.tb00257.x

Source DB:  PubMed          Journal:  Risk Anal        ISSN: 0272-4332            Impact factor:   4.000


  3 in total

1.  Comparative Probabilistic Assessment of Occupational Pesticide Exposures Based on Regulatory Assessments.

Authors:  Jane G Pouzou; Alison C Cullen; Michael G Yost; John C Kissel; Richard A Fenske
Journal:  Risk Anal       Date:  2017-11-06       Impact factor: 4.000

2.  Probabilistic prediction of exposures to arsenic contaminated residential soil.

Authors:  R C Lee; J C Kissel
Journal:  Environ Geochem Health       Date:  1995-12       Impact factor: 4.609

3.  Beyond the RfD: Broad Application of a Probabilistic Approach to Improve Chemical Dose-Response Assessments for Noncancer Effects.

Authors:  Weihsueh A Chiu; Daniel A Axelrad; Chimeddulam Dalaijamts; Chris Dockins; Kan Shao; Andrew J Shapiro; Greg Paoli
Journal:  Environ Health Perspect       Date:  2018-06-28       Impact factor: 9.031

  3 in total

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