Literature DB >> 7972878

Cloning and expression of a cDNA for rat prostaglandin F2 alpha receptor.

J Kitanaka1, H Hasimoto, Y Sugimoto, M Negishi, H Aino, M Gotoh, A Ichikawa, A Baba.   

Abstract

We have cloned a cDNA for rat prostaglandin (PG) F2 alpha receptor from cultured rat astrocytes. The cDNA encodes a polypeptide of 366 amino acids with seven putative transmembrane domains. Specific binding of [3H]PGF2 alpha in membranes of COS-7 cells transfected with the cDNA was displaced with unlabeled PGs in the order of PGF2 alpha > PGD2 > PGE2 > PGI2. In the cDNA-transfected LLC-PK1 cells, PGF2 alpha stimulated phosphoinositide hydrolysis. A significant 4.7-kb mRNA transcript was detected in cultured rat astrocytes and whole brain and pregnant ovary of adult rats by Northern blot analysis.

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Year:  1994        PMID： 7972878     DOI： 10.1016/0090-6980(94)90094-9

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  8 in total

1.  Comprehensive profiling of prostaglandins in human ovarian follicular fluid using mass spectrometry.

Authors:  Bruce Pier; Johnathan W Edmonds; Landon Wilson; Alireza Arabshahi; Ray Moore; G Wright Bates; Jeevan K Prasain; Michael A Miller
Journal:  Prostaglandins Other Lipid Mediat       Date:  2017-11-09       Impact factor: 3.072

2.  Prostaglandin FP receptor inhibitor reduces ischemic brain damage and neurotoxicity.

Authors:  Yun Tai Kim; Sang Kwan Moon; Takayuki Maruyama; Shuh Narumiya; Sylvain Doré
Journal:  Neurobiol Dis       Date:  2012-06-16       Impact factor: 5.996

3.  Prostaglandin F2alpha is required for NMDA receptor-mediated induction of c-fos mRNA in dentate gyrus neurons.

Authors:  L S Lerea; N G Carlson; M Simonato; J D Morrow; J L Roberts; J O McNamara
Journal:  J Neurosci       Date:  1997-01-01       Impact factor: 6.167

4.  Differential modulation of prostaglandin receptor mRNA abundance by prostaglandins in primary cultured rat hepatocytes.

Authors:  Silvia Pérez; Eduardo N Maldonado; Patricia Aspichueta; Begoña Ochoa; Yolanda Chico
Journal:  Mol Cell Biochem       Date:  2004-11       Impact factor: 3.396

5.  Tunicamycin inhibits prostaglandin F2 alpha receptor-mediated phosphoinositide hydrolysis in cultured rat astrocytes.

Authors:  J Kitanaka; T Hamano; M Gotoh; H Hashimoto; A Baba
Journal:  Neurochem Res       Date:  1994-12       Impact factor: 3.996

Review 6.  Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System.

Authors:  Tatsurou Yagami; Hiromi Koma; Yasuhiro Yamamoto
Journal:  Mol Neurobiol       Date:  2015-09-02       Impact factor: 5.590

7.  PGF(2alpha) FP receptor contributes to brain damage following transient focal brain ischemia.

Authors:  Sofiyan Saleem; Abdullah Shafique Ahmad; Takayuki Maruyama; Shuh Narumiya; Sylvain Doré
Journal:  Neurotox Res       Date:  2009-02-11       Impact factor: 3.911

8.  Putative role of prostaglandin receptor in intracerebral hemorrhage.

Authors:  Shekher Mohan; Abdullah S Ahmad; Alexander V Glushakov; Chase Chambers; Sylvain Doré
Journal:  Front Neurol       Date:  2012-10-22       Impact factor: 4.003
  8 in total

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