PURPOSE: To characterize the non-acute abnormalities seen at computed tomography (CT) in patients with sickle cell (SC) disease and a prior history of acute chest syndrome (ACS)-pneumonia. MATERIALS AND METHODS: Twenty-nine patients with SC disease who had experienced one to more than 10 (median, six) previous episodes of ACS-pneumonia were prospectively studied with thin-section CT of the thorax. Scans were graded for interstitial disease and assigned a disease index ranging from 0 to 3. Twenty-four patients underwent pulmonary function tests (PFTs) and measurement of their blood gasses. RESULTS: Twelve of the 29 patients (41%) had significant interstitial disease that was multifocal. A correlation was found between the disease index and number of episodes of ACS-pneumonia (P = .02) but not between the disease index and PFT results. CONCLUSION: Thin-section CT demonstrates significant multifocal interstitial lung abnormalities in 41% of selected patients with SC disease. The pattern is most consistent with scarring from episodes of infarction or infection.
PURPOSE: To characterize the non-acute abnormalities seen at computed tomography (CT) in patients with sickle cell (SC) disease and a prior history of acute chest syndrome (ACS)-pneumonia. MATERIALS AND METHODS: Twenty-nine patients with SC disease who had experienced one to more than 10 (median, six) previous episodes of ACS-pneumonia were prospectively studied with thin-section CT of the thorax. Scans were graded for interstitial disease and assigned a disease index ranging from 0 to 3. Twenty-four patients underwent pulmonary function tests (PFTs) and measurement of their blood gasses. RESULTS: Twelve of the 29 patients (41%) had significant interstitial disease that was multifocal. A correlation was found between the disease index and number of episodes of ACS-pneumonia (P = .02) but not between the disease index and PFT results. CONCLUSION: Thin-section CT demonstrates significant multifocal interstitial lung abnormalities in 41% of selected patients with SC disease. The pattern is most consistent with scarring from episodes of infarction or infection.
Authors: Ursula David Alves; Agnaldo José Lopes; Maria Christina Paixão Maioli; Andrea Ribeiro Soares; Pedro Lopes de Melo; Roberto Mogami Journal: Radiol Bras Date: 2016 Jul-Aug
Authors: A J Lopes; C L Marinho; U D Alves; C E A Gonçalves; P O Silva; E C Botelho; R Bedirian; A R Soares; M C P Maioli Journal: Braz J Med Biol Res Date: 2017-07-20 Impact factor: 2.590
Authors: Yvonne A Dei-Adomakoh; Jane S Afriyie-Mensah; Audrey Forson; Martin Adadey; Thomas A Ndanu; Joseph K Acquaye Journal: Adv Hematol Date: 2019-04-01