Literature DB >> 7971974

Specific tolerance across a discordant xenogeneic transplantation barrier.

L A Lee1, H A Gritsch, J J Sergio, J S Arn, R M Glaser, T Sablinski, D H Sachs, M Sykes.   

Abstract

Successful induction of tolerance across disparate (discordant) species barriers could overcome the organ shortage that presently limits clinical transplantation. We demonstrate here that xenogeneic swine thymic transplants can induce tolerance to swine antigens in mice, while positively selecting functional host CD4+ T cells. Immunologically normal C57BL/10 mice were thymectomized and depleted of T and natural killer cells; then they received transplants of fetal pig thymus and liver fragments. Mature mouse CD4+ T cells developed in the pig thymus grafts and migrated to the periphery. Swine grafts grew markedly and no anti-pig IgG response was produced. Mixed lymphocyte reactions confirmed that the new T cells were functional and were tolerant to pig antigens.

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Year:  1994        PMID： 7971974      PMCID： PMC45126          DOI： 10.1073/pnas.91.23.10864

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  12 in total

1.  Evidence that multiple defects in cell-surface molecule interactions across species differences are responsible for diminished xenogeneic T cell responses.

Authors:  R D Moses; H J Winn; H Auchincloss
Journal:  Transplantation       Date:  1992-01       Impact factor: 4.939

2.  The human antimurine xenogeneic cytotoxic response. I. Dependence on responder antigen-presenting cells.

Authors:  P J Lucas; G M Shearer; S Neudorf; R E Gress
Journal:  J Immunol       Date:  1990-06-15       Impact factor: 5.422

3.  Tolerance of CD8+ T cells developing in parent-->F1 chimeras prepared with supralethal irradiation: step-wise induction of tolerance in the intrathymic and extrathymic environments.

Authors:  H Kosaka; J Sprent
Journal:  J Exp Med       Date:  1993-02-01       Impact factor: 14.307

4.  Strong T cell tolerance in parent----F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy.

Authors:  E K Gao; D Lo; J Sprent
Journal:  J Exp Med       Date:  1990-04-01       Impact factor: 14.307

5.  Thymic epithelium tolerizes for histocompatibility antigens.

Authors:  J Salaün; A Bandeira; I Khazaal; F Calman; M Coltey; A Coutinho; N M Le Douarin
Journal:  Science       Date:  1990-03-23       Impact factor: 47.728

6.  Species-restricted interactions between CD8 and the alpha 3 domain of class I influence the magnitude of the xenogeneic response.

Authors:  M J Irwin; W R Heath; L A Sherman
Journal:  J Exp Med       Date:  1989-10-01       Impact factor: 14.307

7.  The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells.

Authors:  J Bill; O Kanagawa; D L Woodland; E Palmer
Journal:  J Exp Med       Date:  1989-04-01       Impact factor: 14.307

8.  Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogeny.

Authors:  D E Speiser; H Pircher; P S Ohashi; D Kyburz; H Hengartner; R M Zinkernagel
Journal:  J Exp Med       Date:  1992-05-01       Impact factor: 14.307

9.  The concurrent maturation of mouse and human thymocytes in human fetal thymus implanted in NIH-beige-nude-xid mice is associated with the reconstitution of the murine immune system.

Authors:  T R Kollmann; M M Goldstein; H Goldstein
Journal:  J Exp Med       Date:  1993-03-01       Impact factor: 14.307

10.  Specific tolerance induction across a xenogeneic barrier: production of mixed rat/mouse lymphohematopoietic chimeras using a nonlethal preparative regimen.

Authors:  Y Sharabi; I Aksentijevich; T M Sundt; D H Sachs; M Sykes
Journal:  J Exp Med       Date:  1990-07-01       Impact factor: 14.307
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  29 in total

1.  Quantification of baboon thymopoiesis in porcine thymokidney xenografts by the signal-joining T-cell receptor excision circle assay.

Authors:  Aseda Tena; Prashanth Vallabhajosyula; Robert J Hawley; Adam Griesemer; Kazuhiko Yamada; David H Sachs
Journal:  Transplantation       Date:  2011-03-27       Impact factor: 4.939

2.  Xenotransplantation as a model of integrated, multidisciplinary research.

Authors:  Emanuele Cozzi; Erika Bosio; Michela Seveso; Domenico Rubello; Ermanno Ancona
Journal:  Organogenesis       Date:  2009-01       Impact factor: 2.500

3.  Results of gal-knockout porcine thymokidney xenografts.

Authors:  A D Griesemer; A Hirakata; A Shimizu; S Moran; A Tena; H Iwaki; Y Ishikawa; P Schule; J S Arn; S C Robson; J A Fishman; M Sykes; D H Sachs; K Yamada
Journal:  Am J Transplant       Date:  2009-10-21       Impact factor: 8.086

Review 4.  Mixed hematopoietic chimerism and transplantation tolerance.

Authors:  B Nikolic; M Sykes
Journal:  Immunol Res       Date:  1997       Impact factor: 2.829

Review 5.  T-cell-mediated immunological barriers to xenotransplantation.

Authors:  Joseph Scalea; Isabel Hanecamp; Simon C Robson; Kazuhiko Yamada
Journal:  Xenotransplantation       Date:  2012 Jan-Feb       Impact factor: 3.907

6.  Survival and function of CD47-deficient thymic grafts in mice.

Authors:  Yuantao Wang; Hui Wang; Shumei Wang; Yaowen Fu; Yong-Guang Yang
Journal:  Xenotransplantation       Date:  2010 Mar-Apr       Impact factor: 3.907

7.  Reduced positive selection of a human TCR in a swine thymus using a humanized mouse model for xenotolerance induction.

Authors:  Grace Nauman; Chiara Borsotti; Nichole Danzl; Mohsen Khosravi-Maharlooei; Hao-Wei Li; Estefania Chavez; Samantha Stone; Megan Sykes
Journal:  Xenotransplantation       Date:  2019-09-29       Impact factor: 3.907

8.  Preparation of hybrid porcine thymus containing non-human primate thymic epithelial cells in miniature swine.

Authors:  Mitsuhiro Sekijima; Hisashi Sahara; Akira Shimizu; Takehiro Iwanaga; Takahiro Murokawa; Yuichi Ariyoshi; Thomas Pomposelli; Mohsen Khosravi Maharlooei; Megan Sykes; Kazuhiko Yamada
Journal:  Xenotransplantation       Date:  2019-07-10       Impact factor: 3.907

9.  Intra-bone Bone Marrow Transplantation in Pig-to-Nonhuman Primates for the Induction of Tolerance Across Xenogeneic Barriers.

Authors:  Kazuhiko Yamada; Yuichi Ariyoshi; Thomas Pomposelli; Kazuhiro Takeuchi
Journal:  Methods Mol Biol       Date:  2020

Review 10.  Achieving tolerance in pig-to-primate xenotransplantation: reality or fantasy.

Authors:  David H Sachs; Megan Sykes; Kazuhiko Yamada
Journal:  Transpl Immunol       Date:  2008-12-06       Impact factor: 1.708
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