Literature DB >> 7970226

In situ hybridization localization of the Na+ channel beta 1 subunit mRNA in rat CNS neurons.

Y Oh1, S Sashihara, S G Waxman.   

Abstract

Localization of Na+ channel beta 1 subunit (Na beta 1) mRNA was examined in adult rat hippocampus, cerebellum and spinal cord by in situ hybridization histochemistry. In hippocampus, Na beta 1 mRNA was strongly expressed by CA3 followed by CA1 pyramidal cells and dentate granule cells. In cerebellum, strong Na beta 1 mRNA expression was observed in Purkinje cells and moderate expression in granule cells and scattered cells of the molecular layer. In spinal cord, neurons in gray matter exhibited moderate to strong expression of Na beta 1 mRNA. These results provide the first localization study of Na beta 1 mRNA in the CNS, demonstrating a differential expression in different neurons.

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Year:  1994        PMID： 7970226     DOI： 10.1016/0304-3940(94)90885-0

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  7 in total

1.  Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels.

Authors:  Teresa K Aman; Tina M Grieco-Calub; Chunling Chen; Raffaella Rusconi; Emily A Slat; Lori L Isom; Indira M Raman
Journal:  J Neurosci       Date:  2009-02-18       Impact factor: 6.167

Review 2.  Localization and targeting of voltage-dependent ion channels in mammalian central neurons.

Authors:  Helene Vacher; Durga P Mohapatra; James S Trimmer
Journal:  Physiol Rev       Date:  2008-10       Impact factor: 37.312

3.  Functional distribution of three types of Na+ channel on soma and processes of dorsal horn neurones of rat spinal cord.

Authors:  B V Safronov; M Wolff; W Vogel
Journal:  J Physiol       Date:  1997-09-01       Impact factor: 5.182

4.  beta 3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics.

Authors:  K Morgan; E B Stevens; B Shah; P J Cox; A K Dixon; K Lee; R D Pinnock; J Hughes; P J Richardson; K Mizuguchi; A P Jackson
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-29       Impact factor: 11.205

5.  Physiological and morphological development of the rat cerebellar Purkinje cell.

Authors:  Bruce E McKay; Ray W Turner
Journal:  J Physiol       Date:  2005-07-07       Impact factor: 5.182

6.  cAMP-dependent phosphorylation of the tetrodotoxin-resistant voltage-dependent sodium channel SNS.

Authors:  E M Fitzgerald; K Okuse; J N Wood; A C Dolphin; S J Moss
Journal:  J Physiol       Date:  1999-04-15       Impact factor: 5.182

7.  Identification of both GABAA receptors and voltage-activated Na(+) channels as molecular targets of anticonvulsant α-asarone.

Authors:  Ze-Jun Wang; Simon R Levinson; Liqin Sun; Thomas Heinbockel
Journal:  Front Pharmacol       Date:  2014-03-11       Impact factor: 5.810
  7 in total

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