| Literature DB >> 7968373 |
K Chandrasekaran1, T Giordano, D R Brady, J Stoll, L J Martin, S I Rapoport.
Abstract
Brains from 5 patients with Alzheimer's disease (AD) showed a 50%-65% decrease in mRNA levels of the mitochondrial-encoded cytochrome oxidase (COX, a marker of oxidative metabolism) subunits I and III in the middle temporal association neocortex, but not in the primary motor cortex, as compared to 5 control brains. The amount of mitochondrial-encoded 12S rRNA was not altered, nor was the amount of nuclear-encoded lactate dehydrogenase B mRNA (a marker of glycolytic metabolism). These data suggest that the decrease in COX I and III subunits mRNA in affected brain regions may contribute to reduced brain oxidative metabolism in AD.Entities:
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Year: 1994 PMID： 7968373 DOI： 10.1016/0169-328x(94)90147-3
Source DB: PubMed Journal: Brain Res Mol Brain Res ISSN： 0169-328X