| Literature DB >> 7968238 |
C D Wright1, W L Cody, J B Dunbar, A M Doherty, G P Hingorani, S T Rapundalo.
Abstract
The chemotactic response of human neutrophils to endothelins (ET) and ET-derived peptides was examined. ET-1, ET-2, and ET-3 elicited maximum responses at 10(-7), 3.3 x 10(-8) and 10(-7) M, respectively. Relative activities of the peptides at their optimal concentrations were: ET-1, ET-2 > ET-3. The chemotactic activity of ET-1 was localized to its Leu6-Met7-Asp8 segment. Conformation of the disulfide-linked Cys3-Cys11 loop appears to be critical for proper orientation of the chemotactic epitope. In comparison, ET-1 failed to stimulate the neutrophil respiratory burst, degranulation or arachidonic acid metabolism. These results demonstrate the selective chemoattractant activity of endothelins for human neutrophils.Entities:
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Year: 1994 PMID： 7968238 DOI： 10.1016/0024-3205(94)00330-0
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037