Literature DB >> 796697

Mutagenicity of industrial compounds: styrene and its possible metabolite styrene oxide.

N Loprieno, A Abbondandolo, R Barale, S Baroncelli, S Bonatti, G Bronzetti, A Cammellini, C Corsi, G Corti, D Frezza, C Leporini, A Mazzaccaro, R Nieri, D Rosellini, A M Rossi.   

Abstract

Styrene and its presumed metabolite, styrene oxide, were tested for their mutagenic effect on a forward mutation system of yeast and of Chinese hamster cells, and on a gene-conversion system of yeast. Experiments with liver microsomal preparations and host-mediated assay with yeast were also carried out. Styrene oxide was mutagenic in all test systems. Styrene was mutagenic only in the host-mediated assay.

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Year:  1976        PMID： 796697     DOI： 10.1016/0165-1218(76)90030-6

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  5 in total

1.  Placental transfer and tissue distribution of 14C-styrene: an autoradiographic study in mice.

Authors:  R Kishi; Y Katakura; T Okui; H Ogawa; T Ikeda; H Miyake
Journal:  Br J Ind Med       Date:  1989-06

Review 2.  Critical review of styrene genotoxicity focused on the mutagenicity/clastogenicity literature and using current organization of economic cooperation and development guidance.

Authors:  Martha M Moore; Lynn H Pottenger; Tamara House-Knight
Journal:  Environ Mol Mutagen       Date:  2019-03-13       Impact factor: 3.216

3.  Biological monitoring of styrene in the reinforced plastics industry in Emilia Romagna, Italy.

Authors:  C Galassi; M Kogevinas; G Ferro; M Biocca
Journal:  Int Arch Occup Environ Health       Date:  1993       Impact factor: 3.015

4.  Uptake, distribution, metabolism, and elimination of styrene in man. A comparison between single exposure and co-exposure with acetone.

Authors:  E Wigaeus; A Löf; M B Nordqvist
Journal:  Br J Ind Med       Date:  1984-11

5.  Mutagenicity and chromosomal aberrations as an analytical tool for in vitro detection of mammalian enzyme-mediated formation of reactive metabolites.

Authors:  H Greim; D Bimboes; G Egert; W Göggelmann; M Krämer
Journal:  Arch Toxicol       Date:  1977-12-30       Impact factor: 5.153
  5 in total

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