OBJECTIVE: To describe the association between apolipoprotein E alleles (epsilon 2, epsilon 3, and epsilon 4), dyslipidemias, and coronary heart disease (CHD). DESIGN: Cross-sectional prevalence study. SETTING AND PARTICIPANTS: Community-based sample of men (n = 1034) and women (n = 916) aged 40 to 77 years who are participating in a long-term study of cardiovascular disease. Study participants underwent fasting lipid measurements, coronary risk factor determinations, and a comprehensive evaluation for the presence of current or previous CHD. RESULTS: Compared with the epsilon 3 allele, the epsilon 4 allele was associated with elevated low-density lipoprotein cholesterol values (> or = 4.14 mmol/L [160 mg/dL]) in women, the epsilon 2 and epsilon 4 alleles were associated with moderately elevated triglyceride values (> or = 2.82 mmol/L [250 mg/dL]) in men, and the epsilon 2 allele was associated with severely elevated triglyceride values (> or = 5.64 mmol/L [500 mg/dL]) in men. The apolipoprotein E alleles were not associated with hypertension, obesity, smoking, or diabetes, but the epsilon 4 allele frequency was reduced in women after 60 years of age. The age-adjusted prevalence of CHD was associated with the epsilon 4 allele in both men (relative odds = 1.53, P = .04) and women (relative odds = 1.99, P = .05). In analyses for women and for both sexes combined, this relation persisted after adjustment by hypertension, smoking, obesity, diabetes, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. CONCLUSIONS: Apolipoprotein E alleles are important genetic markers for dyslipidemia and CHD. The estimated CHD odds associated with the epsilon 4 allele appears to be greater than that for any other known genetic lipid abnormality, and the association of the epsilon 4 allele with CHD remains significant in women and both sexes combined after adjustment by traditional coronary risk factors and lipids.
OBJECTIVE: To describe the association between apolipoprotein E alleles (epsilon 2, epsilon 3, and epsilon 4), dyslipidemias, and coronary heart disease (CHD). DESIGN: Cross-sectional prevalence study. SETTING AND PARTICIPANTS: Community-based sample of men (n = 1034) and women (n = 916) aged 40 to 77 years who are participating in a long-term study of cardiovascular disease. Study participants underwent fasting lipid measurements, coronary risk factor determinations, and a comprehensive evaluation for the presence of current or previous CHD. RESULTS: Compared with the epsilon 3 allele, the epsilon 4 allele was associated with elevated low-density lipoprotein cholesterol values (> or = 4.14 mmol/L [160 mg/dL]) in women, the epsilon 2 and epsilon 4 alleles were associated with moderately elevated triglyceride values (> or = 2.82 mmol/L [250 mg/dL]) in men, and the epsilon 2 allele was associated with severely elevated triglyceride values (> or = 5.64 mmol/L [500 mg/dL]) in men. The apolipoprotein E alleles were not associated with hypertension, obesity, smoking, or diabetes, but the epsilon 4 allele frequency was reduced in women after 60 years of age. The age-adjusted prevalence of CHD was associated with the epsilon 4 allele in both men (relative odds = 1.53, P = .04) and women (relative odds = 1.99, P = .05). In analyses for women and for both sexes combined, this relation persisted after adjustment by hypertension, smoking, obesity, diabetes, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. CONCLUSIONS:Apolipoprotein E alleles are important genetic markers for dyslipidemia and CHD. The estimated CHD odds associated with the epsilon 4 allele appears to be greater than that for any other known genetic lipid abnormality, and the association of the epsilon 4 allele with CHD remains significant in women and both sexes combined after adjustment by traditional coronary risk factors and lipids.
Authors: Marguerite R Irvin; Edmond K Kabagambe; Hemant K Tiwari; Laurence D Parnell; Robert J Straka; Michael Tsai; Jose M Ordovas; Donna K Arnett Journal: Circ Cardiovasc Genet Date: 2010-08-21
Authors: Erica P Gunderson; Rachel A Whitmer; Cora E Lewis; Charles P Quesenberry; Delia Smith West; Stephen Sidney Journal: J Womens Health (Larchmt) Date: 2005-12 Impact factor: 2.681
Authors: Nicola Filippini; Bradley J MacIntosh; Morgan G Hough; Guy M Goodwin; Giovanni B Frisoni; Stephen M Smith; Paul M Matthews; Christian F Beckmann; Clare E Mackay Journal: Proc Natl Acad Sci U S A Date: 2009-04-08 Impact factor: 11.205
Authors: Neena Srivastava; B R Achyut; Jai Prakash; C G Agarwal; D C Pant; Balraj Mittal Journal: Mol Cell Biochem Date: 2008-05-04 Impact factor: 3.396
Authors: M X Tang; G Maestre; W Y Tsai; X H Liu; L Feng; W Y Chung; M Chun; P Schofield; Y Stern; B Tycko; R Mayeux Journal: Am J Hum Genet Date: 1996-03 Impact factor: 11.025
Authors: H Payami; S Zareparsi; K R Montee; G J Sexton; J A Kaye; T D Bird; C E Yu; E M Wijsman; L L Heston; M Litt; G D Schellenberg Journal: Am J Hum Genet Date: 1996-04 Impact factor: 11.025