Effects of sedatives and their solvents on the neutrophil granulocyte function.

We have examined the effects of commercially available preparations and drug-free solvents of Midazolam (Dormicum) and Propofol (Disoprivan) by N-formyl-methionyl-leucyl-phenylalanine (FMLP) -induced polymorphonuclear cell (PMN) chemiluminescence system. In the case of propofol and drug-free solvent, PMN chemiluminescence was suppressed. With Midazolam, only the active drug depressed PMN chemiluminescence.