Literature DB >> 7966233

Comparison of the efficacy of AZT and PMEA treatment against acute SIVmne infection in macaques.

C C Tsai1, K E Follis, R Grant, A Sabo, R Nolte, C Bartz, N Bischofberger, R Benveniste.   

Abstract

The antiretroviral drugs azidothymidine (AZT) and 9-(-2-phosphonyl-methoxyethyl)adenine (PMEA) were individually tested for prevention of simian immunodeficiency virus (SIVmne) infection in macaques (Macaca fascicularis). Macaques were pretreated with either drug before inoculation with SIVmne, and drug treatment was continued for four weeks. The virus, antibody, and clinical status of the macaques was monitored for up to 36 weeks following inoculation. While AZT prophylaxis resulted in reduced virus load in some macaques, PMEA prophylaxis was highly efficacious in preventing acute SIVmne infection.

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Year:  1994        PMID： 7966233     DOI： 10.1111/j.1600-0684.1994.tb00119.x

Source DB:  PubMed          Journal:  J Med Primatol        ISSN： 0047-2565            Impact factor:   0.667


  7 in total

1.  Simian immunodeficiency virus disease course is predicted by the extent of virus replication during primary infection.

Authors:  S I Staprans; P J Dailey; A Rosenthal; C Horton; R M Grant; N Lerche; M B Feinberg
Journal:  J Virol       Date:  1999-06       Impact factor: 5.103

2.  MDL 74,968, a new acyclonucleotide analog: activity against human immunodeficiency virus in vitro and in the hu-PBL-SCID.beige mouse model of infection.

Authors:  C G Bridges; D L Taylor; P S Ahmed; T M Brennan; J M Hornsperger; J F Navé; P Casara; A S Tyms
Journal:  Antimicrob Agents Chemother       Date:  1996-05       Impact factor: 5.191

3.  Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine.

Authors:  L Naesens; J Balzarini; N Bischofberger; E De Clercq
Journal:  Antimicrob Agents Chemother       Date:  1996-01       Impact factor: 5.191

4.  Safety of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in patients with human immunodeficiency virus infection: a pilot study.

Authors:  S Arends; E van Halteren; W Kamp; J Schokker
Journal:  Pharm World Sci       Date:  1996-01

Review 5.  In search of a selective antiviral chemotherapy.

Authors:  E De Clercq
Journal:  Clin Microbiol Rev       Date:  1997-10       Impact factor: 26.132

6.  Post-exposure prophylaxis for SIV revisited: animal model for HIV prevention.

Authors:  Peter Emau; Yonghou Jiang; Michael B Agy; Baoping Tian; Girma Bekele; Che-Chung Tsai
Journal:  AIDS Res Ther       Date:  2006-11-28       Impact factor: 2.250

7.  Controlling the HIV/AIDS epidemic: current status and global challenges.

Authors:  Thorsten Demberg; Marjorie Robert-Guroff
Journal:  Front Immunol       Date:  2012-08-14       Impact factor: 7.561
  7 in total

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