Literature DB >> 7966228

Viral genetic determinants in SIVsmmPBj pathogenesis.

F J Novembre1, M M Saucier, V M Hirsch, P R Johnson, H M McClure.   

Abstract

A variant simian immunodeficiency virus (SIV) from sooty mangabeys, SIVsmmPBj, induces an acutely lethal disease in pigtailed macaques (Macaca nemestrina). This study further characterizes the viral genetic determinants involved in this acutely lethal disease. We have generated chimeric molecular clones constructed between SIVsmmPBj and either SIVsmH4 or SIVsmm9 to analyze the role of the 5' half of the genome and the envelope gene in the induction of acute disease. These studies suggest that the gag and gp40 of SIVsmmPBj are required for the development of lethal disease, and an additional determinant in the central regulatory gene region of the SIVsmmPBj genome is also required.

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Year:  1994        PMID： 7966228     DOI： 10.1111/j.1600-0684.1994.tb00114.x

Source DB:  PubMed          Journal:  J Med Primatol        ISSN： 0047-2565            Impact factor:   0.667


  9 in total

1.  Biologic studies of chimeras of highly and moderately virulent molecular clones of simian immunodeficiency virus SIVsmPBj suggest a critical role for envelope in acute AIDS virus pathogenesis.

Authors:  M Haddrick; C R Brown; R Plishka; A Buckler-White; V M Hirsch; H Ginsberg
Journal:  J Virol       Date:  2001-07       Impact factor: 5.103

Review 2.  Going wild: lessons from naturally occurring T-lymphotropic lentiviruses.

Authors:  Sue VandeWoude; Cristian Apetrei
Journal:  Clin Microbiol Rev       Date:  2006-10       Impact factor: 26.132

3.  Longitudinal diffusion tensor imaging and perfusion MRI investigation in a macaque model of neuro-AIDS: a preliminary study.

Authors:  Chunxia Li; Xiaodong Zhang; Amelia Komery; Yingxia Li; Francis J Novembre; James G Herndon
Journal:  Neuroimage       Date:  2011-06-01       Impact factor: 6.556

4.  Characteristics of a pathogenic molecular clone of an end-stage serum-derived variant of simian immunodeficiency virus (SIV(F359)).

Authors:  L Holterman; R Dubbes; J Mullins; G Learn; H Niphuis; W Koornstra; G Koopman; E M Kuhn; A Wade-Evans; B Rosenwirth; J Haaijman; J Heeney
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

5.  Postinoculation PMPA treatment, but not preinoculation immunomodulatory therapy, protects against development of acute disease induced by the unique simian immunodeficiency virus SIVsmmPBj.

Authors:  S Hodge; J de Rosayro; A Glenn; I C Ojukwu; S Dewhurst; H M McClure; N Bischofberger; D C Anderson; S A Klumpp; F J Novembre
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

6.  The ITAM in Nef influences acute pathogenesis of AIDS-inducing simian immunodeficiency viruses SIVsm and SIVagm without altering kinetics or extent of viremia.

Authors:  Houman Dehghani; Charles R Brown; Ronald Plishka; Alicia Buckler-White; Vanessa M Hirsch
Journal:  J Virol       Date:  2002-05       Impact factor: 5.103

7.  A lymph node-derived cytopathic simian immunodeficiency virus Mne variant replicates in nonstimulated peripheral blood mononuclear cells.

Authors:  J T Kimata; A Mozaffarian; J Overbaugh
Journal:  J Virol       Date:  1998-01       Impact factor: 5.103

8.  The U3 promoter and the nef gene of simian immunodeficiency virus (SIV) smmPBj1.9 do not confer acute pathogenicity upon SIVagm.

Authors:  S Wagener; M T Dittmar; B Beer; R König; R Plesker; S Norley; R Kurth; K Cichutek
Journal:  J Virol       Date:  1998-04       Impact factor: 5.103

9.  The U3 promoter region of the acutely lethal simian immunodeficiency virus clone smmPBj1.9 confers related biological activity on the apathogenic clone agm3mc.

Authors:  M T Dittmar; K Cichutek; P N Fultz; R Kurth
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205
  9 in total

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