Literature DB >> 7966226

Cellular immune responses in rhesus macaques infected rectally with low dose simian immunodeficiency virus.

M S Salvato1, P Emau, M Malkovsky, K T Schultz, E Johnson, C D Pauza.   

Abstract

Monkeys infected rectally with low dose simian immunodeficiency virus (SIV) were resistant to high dose challenge with SIV. Peripheral blood mononuclear cells (PBMC) from two of four challenged monkeys were unable to support SIV replication in vitro unless cultures were depleted of CD8+ lymphocytes. Monkeys that had survived high dose rectal infection with SIV also suppressed virus replication in cultured PBMC. PBMC from uninfected monkeys supported virus replication in both unfractionated and CD8-depleted cultures. Virus-suppressive activity of PBMC may be an important correlate of protective immunity in AIDS.

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Year:  1994        PMID： 7966226     DOI： 10.1111/j.1600-0684.1994.tb00112.x

Source DB:  PubMed          Journal:  J Med Primatol        ISSN： 0047-2565            Impact factor:   0.667


  10 in total

1.  Mucosal immunization with Salmonella typhimurium expressing Lassa virus nucleocapsid protein cross-protects mice from lethal challenge with lymphocytic choriomeningitis virus.

Authors:  M Djavani; C Yin; I S Lukashevich; J Rodas; S K Rai; M S Salvato
Journal:  J Hum Virol       Date:  2001 Mar-Apr

Review 2.  Mechanisms of resistance to HIV infection.

Authors:  W A Paxton; R A Koup
Journal:  Springer Semin Immunopathol       Date:  1997

3.  Protective immunity to HIV-1 in SCID/beige mice reconstituted with peripheral blood lymphocytes of exposed but uninfected individuals.

Authors:  C Zhang; Y Cui; S Houston; L J Chang
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-10       Impact factor: 11.205

4.  High major histocompatibility complex-unrestricted lysis of simian immunodeficiency virus envelope-expressing cells predisposes macaques to rapid AIDS progression.

Authors:  C Yin; M S Wu; C D Pauza; M S Salvato
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

5.  CD4+-T-cell and CD20+-B-cell changes predict rapid disease progression after simian-human immunodeficiency virus infection in macaques.

Authors:  K K Steger; M Dykhuizen; J L Mitchen; P W Hinds; B L Preuninger; M Wallace; J Thomson; D C Montefiori; Y Lu; C D Pauza
Journal:  J Virol       Date:  1998-02       Impact factor: 5.103

6.  Mucosal arenavirus infection of primates can protect them from lethal hemorrhagic fever.

Authors:  Juan D Rodas; Igor S Lukashevich; Juan C Zapata; Cristiana Cairo; Ilia Tikhonov; Mahmoud Djavani; C David Pauza; Maria S Salvato
Journal:  J Med Virol       Date:  2004-03       Impact factor: 2.327

7.  Intrarectal transmission of simian immunodeficiency virus in rhesus macaques: selective amplification and host responses to transient or persistent viremia.

Authors:  P Trivedi; D Horejsh; S B Hinds; I I Hinds PW; M S Wu; M S Salvato; C D Pauza
Journal:  J Virol       Date:  1996-10       Impact factor: 5.103

8.  Occult systemic infection and persistent simian immunodeficiency virus (SIV)-specific CD4(+)-T-cell proliferative responses in rhesus macaques that were transiently viremic after intravaginal inoculation of SIV.

Authors:  M B McChesney; J R Collins; D Lu; X Lu; J Torten; R L Ashley; M W Cloyd; C J Miller
Journal:  J Virol       Date:  1998-12       Impact factor: 5.103

9.  Attenuated disease in SIV-infected macaques treated with a monoclonal antibody against FasL.

Authors:  Maria S Salvato; C Cameron Yin; Hideo Yagita; Toshihiro Maeda; Ko Okumura; Ilia Tikhonov; C David Pauza
Journal:  Clin Dev Immunol       Date:  2007

Review 10.  Pathogen Dose in Animal Models of Hemorrhagic Fever Virus Infections and the Potential Impact on Studies of the Immune Response.

Authors:  Bryce M Warner
Journal:  Pathogens       Date:  2021-03-01
  10 in total

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