PURPOSE: Intravascular papillary endothelial hyperplasia (IPEH) is a benign, nonneoplastic, vascular lesion, that is characterized histologically by papillary fronds lined by proliferating endothelium: it is thought to represent an unusual form of organizing thrombus. It may develop in a distended vessel or in association with other vascular lesions. The main significance of IPEH is its microscopic resemblance to angiosarcoma and possible misinterpretation as such. METHODS: We report the clinicopathologic features of 18 examples of IPEH of the oral soft tissues and lips, and review such features of 55 previously reported oral cases. RESULTS: The lips and tongue were most frequently involved and a female predilection was evident. Histologically, the pure form of IPEH was more commonly encountered. CONCLUSION: The differential diagnosis and possible histogenesis of the lesion are discussed.
PURPOSE:Intravascular papillary endothelial hyperplasia (IPEH) is a benign, nonneoplastic, vascular lesion, that is characterized histologically by papillary fronds lined by proliferating endothelium: it is thought to represent an unusual form of organizing thrombus. It may develop in a distended vessel or in association with other vascular lesions. The main significance of IPEH is its microscopic resemblance to angiosarcoma and possible misinterpretation as such. METHODS: We report the clinicopathologic features of 18 examples of IPEH of the oral soft tissues and lips, and review such features of 55 previously reported oral cases. RESULTS: The lips and tongue were most frequently involved and a female predilection was evident. Histologically, the pure form of IPEH was more commonly encountered. CONCLUSION: The differential diagnosis and possible histogenesis of the lesion are discussed.
Authors: Alexandra Fontes; Marcia Sampaio Campos; Suzana C O M de Sousa; Marília Trierveiler Martins; Fabio Daumas Nunes Journal: Odontology Date: 2011-01-27 Impact factor: 2.634
Authors: Chiara Mignogna; Ida Barca; Anna Di Vito; Francesca Puleo; Natalia Malara; Amerigo Giudice; Mario Giudice; Tullio Barni; Giuseppe Donato; Maria Giulia Cristofaro Journal: Mol Clin Oncol Date: 2016-12-23