Literature DB >> 7964782

Antimitotic and cytotoxic flavonols from Zieridium pseudobtusifolium and Acronychia porteri.

J J Lichius1, O Thoison, A Montagnac, M Païs, F Guéritte-Voegelein, T Sévenet, J P Cosson, A H Hadi.   

Abstract

Bioassay-guided fractionation of the extracts of Zieridium pseudobtusifolium and Acronychia porteri led to the isolation of 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone [1], which showed activity against (KB) human nasopharyngeal carcinoma cells (IC50 0.04 micrograms/ml) and inhibited tubulin assembly into microtubules (IC50 12 microM). Two other known flavonols, digicitrin [2] and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone [5], were also isolated together with three new ones, 3-O-demethyldigicitrin [3], 3,5,3'-trihydroxy-6,7,8,4'-tetramethoxyflavone [4], and 3,5-dihydroxy-6,7,8,3',4'-pentamethoxyflavone [6]. All of these flavonols showed cytotoxic activity against KB cells.

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Year:  1994        PMID： 7964782     DOI： 10.1021/np50109a024

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  5 in total

1.  Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1.

Authors:  Kanokkarn Phromnoi; Sahdeo Prasad; Subash C Gupta; Ramaswamy Kannappan; Simone Reuter; Pornngarm Limtrakul; Bharat B Aggarwal
Journal:  Mol Pharmacol       Date:  2011-08-04       Impact factor: 4.436

2.  N-Benzylation of 6-aminoflavone by reductive amination and efficient access to some novel anticancer agents via topoisomerase II inhibition.

Authors:  Nitin M Thorat; Aniket P Sarkate; Deepak K Lokwani; Shailee V Tiwari; Rajaram Azad; Shankar R Thopate
Journal:  Mol Divers       Date:  2020-04-05       Impact factor: 2.943

3.  A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.

Authors:  Kanokkarn Phromnoi; Simone Reuter; Bokyung Sung; Sahdeo Prasad; Ramaswamy Kannappan; Vivek R Yadav; Wisinee Chanmahasathien; Pornngarm Limtrakul; Bharat B Aggarwal
Journal:  Mol Pharmacol       Date:  2010-10-07       Impact factor: 4.436

4.  A Dihydroxy-pentamethoxyflavone from Gardenia obtusifolia suppresses proliferation and promotes apoptosis of tumor cells through modulation of multiple cell signaling pathways.

Authors:  Kanokkarn Phromnoi; Simone Reuter; Bokyung Sung; Pornngarm Limtrakul; Bharat B Aggarwal
Journal:  Anticancer Res       Date:  2010-09       Impact factor: 2.480

5.  A pentamethoxylated flavone from Glycosmis ovoidea promotes apoptosis through the intrinsic pathway and inhibits migration of MCF-7 breast cancer cells.

Authors:  Gerardo D Anaya-Eugenio; Peter J Blanco Carcache; Tran Ngoc Ninh; Yulin Ren; Djaja D Soejarto; A Douglas Kinghorn
Journal:  Phytother Res       Date:  2020-10-30       Impact factor: 5.878
  5 in total

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