Literature DB >> 7964470

The specific recognition by macrophages of CD8+,CD45RO+ T cells undergoing apoptosis: a mechanism for T cell clearance during resolution of viral infections.

A N Akbar1, J Savill, W Gombert, M Bofill, N J Borthwick, F Whitelaw, J Grundy, G Janossy, M Salmon.   

Abstract

During viral infections, CD8+,CD45RO+ T populations expand. These primed cells express abundant levels of cytoplasmic granules that contain perforin and TIA-1. Recent work has suggested that the majority of this CD8+ population downregulates Bcl-2 protein expression and is destined to undergo apoptosis. In this study we have investigated the elimination of these apoptotic CD8+ T cells by both human monocyte-derived and murine bone marrow macrophages. We have found that these phagocytes recognize and ingest both apoptotic CD8+ and CD4+ T cells using an alpha v beta 3 (vitronectin receptor)/CD36/thrombospondin recognition system, with the same receptors being used in the recognition of apoptotic neutrophils. These data provide new evidence for a mechanism that enables the clearance of greatly increased populations of CD8+ effector cells which are found during viral infections. This enables cellular homeostasis to occur in the host upon resolution of viral diseases in vivo.

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Year:  1994        PMID： 7964470      PMCID： PMC2191717          DOI： 10.1084/jem.180.5.1943

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  13 in total

1.  Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.

Authors:  J Savill; N Hogg; Y Ren; C Haslett
Journal:  J Clin Invest       Date:  1992-10       Impact factor: 14.808

2.  Expression of CD45R0 (UCHL1) by CD4+ and CD8+ T cells as a sign of in vivo activation in infectious mononucleosis.

Authors:  T Miyawaki; Y Kasahara; H Kanegane; K Ohta; T Yokoi; A Yachie; N Taniguchi
Journal:  Clin Exp Immunol       Date:  1991-03       Impact factor: 4.330

3.  Immune exhaustion: driving virus-specific CD8+ T cells to death.

Authors:  P C Doherty
Journal:  Trends Microbiol       Date:  1993-09       Impact factor: 17.079

4.  Long-term T-cell-mediated immunity to Epstein-Barr virus.

Authors:  A B Rickinson; D J Moss; L E Wallace; M Rowe; I S Misko; M A Epstein; J H Pope
Journal:  Cancer Res       Date:  1981-11       Impact factor: 12.701

5.  Monoclonal antibodies detecting discrete epitopes of human perforin.

Authors:  M Geisberg; J A Trapani; B Dupont
Journal:  Tissue Antigens       Date:  1990-05

6.  Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

Authors:  V A Fadok; D R Voelker; P A Campbell; J J Cohen; D L Bratton; P M Henson
Journal:  J Immunol       Date:  1992-04-01       Impact factor: 5.422

7.  Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules.

Authors:  E R Podack; J D Young; Z A Cohn
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

8.  The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis.

Authors:  M Salmon; D Pilling; N J Borthwick; N Viner; G Janossy; P A Bacon; A N Akbar
Journal:  Eur J Immunol       Date:  1994-04       Impact factor: 5.532

9.  Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells.

Authors:  V A Fadok; J S Savill; C Haslett; D L Bratton; D E Doherty; P A Campbell; P M Henson
Journal:  J Immunol       Date:  1992-12-15       Impact factor: 5.422

10.  bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages.

Authors:  E Lagasse; I L Weissman
Journal:  J Exp Med       Date:  1994-03-01       Impact factor: 14.307
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  21 in total

1.  Recognition and phagocytosis of apoptotic T cells by resident murine tissue macrophages require multiple signal transduction events.

Authors:  Bin Hu; Antonello Punturieri; Jill Todt; Joanne Sonstein; Timothy Polak; Jeffrey L Curtis
Journal:  J Leukoc Biol       Date:  2002-05       Impact factor: 4.962

2.  Selective migration of highly differentiated primed T cells, defined by low expression of CD45RB, across human umbilical vein endothelial cells: effects of viral infection on transmigration.

Authors:  N J Borthwick; A N Akbar; L P MacCormac; M Lowdell; J L Craigen; I Hassan; J E Grundy; M Salmon; K L Yong
Journal:  Immunology       Date:  1997-02       Impact factor: 7.397

3.  Monocytes recruited to the lungs of mice during immune inflammation ingest apoptotic cells poorly.

Authors:  Jeffrey H Jennings; Derek J Linderman; Bin Hu; Joanne Sonstein; Jeffrey L Curtis
Journal:  Am J Respir Cell Mol Biol       Date:  2004-11-24       Impact factor: 6.914

4.  Reconstitution of CD4+ T cell responses in HIV-1 infected individuals initiating highly active antiretroviral therapy (HAART) is associated with renewed interleukin-2 production and responsiveness.

Authors:  G A D Hardy; N Imami; A K Sullivan; A Pires; C T Burton; M R Nelson; B G Gazzard; F M Gotch
Journal:  Clin Exp Immunol       Date:  2003-10       Impact factor: 4.330

5.  Intracellular calcium signalling patterns reflect the differentiation status of human T cells.

Authors:  H P Arrol; L D Church; P A Bacon; S P Young
Journal:  Clin Exp Immunol       Date:  2008-05-05       Impact factor: 4.330

Review 6.  Recognition of apoptotic cells by phagocytes.

Authors:  S P Hart; C Haslett; I Dransfield
Journal:  Experientia       Date:  1996-10-31

7.  Multiple systems for recognition of apoptotic lymphocytes by macrophages.

Authors:  D Pradhan; S Krahling; P Williamson; R A Schlegel
Journal:  Mol Biol Cell       Date:  1997-05       Impact factor: 4.138

8.  A novel flow cytometric method for quantifying phagocytosis of apoptotic cells.

Authors:  K L Hess; G F Babcock; D S Askew; J M Cook-Mills
Journal:  Cytometry       Date:  1997-02-01

9.  Factors that influence activated CD8+ T-cell apoptosis in patients with acute herpesvirus infections: loss of costimulatory molecules CD28, CD5 and CD6 but relative maintenance of Bax and Bcl-X expression.

Authors:  N J Borthwick; M Bofill; I Hassan; P Panayiotidis; G Janossy; M Salmon; A N Akbar
Journal:  Immunology       Date:  1996-08       Impact factor: 7.397

10.  Activation of the Fas receptor on lung eosinophils leads to apoptosis and the resolution of eosinophilic inflammation of the airways.

Authors:  S Tsuyuki; C Bertrand; F Erard; A Trifilieff; J Tsuyuki; M Wesp; G P Anderson; A J Coyle
Journal:  J Clin Invest       Date:  1995-12       Impact factor: 14.808
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