| Literature DB >> 7963704 |
J H Kao1, P J Chen, M Y Lai, P M Yang, J C Sheu, T H Wang, D S Chen.
Abstract
Twenty patients with chronic hepatitis C virus (HCV) infection and acute exacerbations (group A) were studied by polymerase chain reaction with genotype-specific primers to explore the role of mixed infections of HCV in acute exacerbations of chronic type C hepatitis. Another 26 patients who did not have acute exacerbation were matched controls (group B). Eleven (55%) of the group A patients had heterologous HCV, and their mean age was significantly younger than that of the 9 without heterologous infection (55 vs. 67 years, P < .05). In contrast, only 2 group B patients (7.7%) had heterologous HCV infection. In 10 of 13 patients with heterologous HCV infection, type III/2a virus emerged on type II/1b HCV, and viral interference was observed in half of them. The results support that mixed infections of HCV may be important in acute exacerbations of chronic type C hepatitis.Entities:
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Year: 1994 PMID： 7963704 DOI： 10.1093/infdis/170.5.1128
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226