Literature DB >> 7963598

Development of a whole blood assay to measure T cell responses to leprosy: a new tool for immuno-epidemiological field studies of leprosy immunity.

R E Weir1, A R Morgan, W J Britton, C R Butlin, H M Dockrell.   

Abstract

A whole blood assay is described to measure T cell mediated immune responses to leprosy and provide an alternative to the conventional lymphocyte transformation test. Optimal conditions were defined for the whole blood assay, and interferon-gamma measurement was found to be a more sensitive way of measuring responses than tritiated thymidine incorporation. The assay was shown to be useful for investigating responses to a range of leprosy antigens. A whole blood assay has the advantages of being quick, simple and requiring only a small volume of blood, making it more appropriate as an immuno-epidemiological field test in leprosy endemic areas.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7963598     DOI： 10.1016/0022-1759(94)90353-0

Source DB:  PubMed          Journal:  J Immunol Methods        ISSN： 0022-1759            Impact factor:   2.303


  28 in total

1.  Presence of human T-cell responses to the Mycobacterium leprae 45-kilodalton antigen reflects infection with or exposure to M. leprae.

Authors:  A Macfarlane; R Mondragon-Gonzalez; F Vega-Lopez; B Wieles; J de Pena; O Rodriguez; R Suarez y de la Torre; R R de Vries; T H Ottenhoff; H M Dockrell
Journal:  Clin Diagn Lab Immunol       Date:  2001-05

2.  Antigen discovery: a postgenomic approach to leprosy diagnosis.

Authors:  Romulo Aráoz; Nadine Honoré; Sungae Cho; Jong-Pill Kim; Sang-Nae Cho; Marc Monot; Caroline Demangel; Patrick J Brennan; Stewart T Cole
Journal:  Infect Immun       Date:  2006-01       Impact factor: 3.441

3.  Vitamin A supplementation increases ratios of proinflammatory to anti-inflammatory cytokine responses in pregnancy and lactation.

Authors:  S E Cox; P Arthur; B R Kirkwood; K Yeboah-Antwi; E M Riley
Journal:  Clin Exp Immunol       Date:  2006-06       Impact factor: 4.330

4.  Mycobacterium tuberculosis region of difference (RD) 2 antigen Rv1985c and RD11 antigen Rv3425 have the promising potential to distinguish patients with active tuberculosis from M. bovis BCG-vaccinated individuals.

Authors:  Sen Wang; Jiazhen Chen; Ying Zhang; Ni Diao; Shu Zhang; Jing Wu; Chanyi Lu; Feifei Wang; Yan Gao; Lingyun Shao; Jialin Jin; Xinhua Weng; Wenhong Zhang
Journal:  Clin Vaccine Immunol       Date:  2012-11-07

5.  Results of multiple diagnostic tests for Mycobacterium avium subsp. paratuberculosis in patients with inflammatory bowel disease and in controls.

Authors:  M T Collins; G Lisby; C Moser; D Chicks; S Christensen; M Reichelderfer; N Høiby; B A Harms; O O Thomsen; U Skibsted; V Binder
Journal:  J Clin Microbiol       Date:  2000-12       Impact factor: 5.948

Review 6.  Correlates of protective immunity to Mycobacterium tuberculosis in humans.

Authors:  J J Ellner; C S Hirsch; C C Whalen
Journal:  Clin Infect Dis       Date:  2000-06       Impact factor: 9.079

7.  Down-regulation of specific antigen-driven cytokine production in a population with endemic Schistosoma japonicum infection.

Authors:  L Shen; Z S Zhang; H W Wu; R E Weir; Z W Xie; L S Hu; S Z Chen; M J Ji; C Su; Y Zhang; Q D Bickle; S N Cousens; M G Taylor; G L Wu
Journal:  Clin Exp Immunol       Date:  2002-08       Impact factor: 4.330

8.  What has Karonga taught us? Tuberculosis studied over three decades.

Authors:  A C Crampin; J R Glynn; P E M Fine
Journal:  Int J Tuberc Lung Dis       Date:  2009-02       Impact factor: 2.373

9.  The tuberculin skin test (TST) is affected by recent BCG vaccination but not by exposure to non-tuberculosis mycobacteria (NTM) during early life.

Authors:  Sarah Burl; Uche J Adetifa; Momodou Cox; Ebrima Touray; Hilton Whittle; Helen McShane; Sarah L Rowland-Jones; Katie L Flanagan
Journal:  PLoS One       Date:  2010-08-19       Impact factor: 3.240

Review 10.  Whole blood assay and visceral leishmaniasis: Challenges and promises.

Authors:  Om Prakash Singh; Shyam Sundar
Journal:  Immunobiology       Date:  2014-01-31       Impact factor: 3.144
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.