| Literature DB >> 7962075 |
B Baccetti1, A Benedetto, A G Burrini, G Collodel, E C Ceccarini, N Crisà, A Di Caro, M Estenoz, A R Garbuglia, A Massacesi.
Abstract
By immunocytochemistry and in situ hybridization at the electron microscopy level, and by the PCR technique, we have shown that HIV-1 binds and enters normal sperm; that viral particles, their antigens, and nucleic acid are present in sperm from HIV-1 infected men; and that such sperm can transfer HIV-1 like particles to normal human oocytes. We also present evidence that a galactosylceramide-like compound is present on the sperm membrane and could function as an alternative receptor for HIV.Entities:
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Year: 1994 PMID： 7962075 PMCID： PMC2200050 DOI： 10.1083/jcb.127.4.903
Source DB: PubMed Journal: J Cell Biol ISSN： 0021-9525 Impact factor: 10.539