Literature DB >> 7961623

Creation of an inositol 1,4,5-trisphosphate-sensitive Ca2+ store in secretory granules of insulin-producing cells.

O Blondel1, G I Bell, M Moody, R J Miller, S J Gibbons.   

Abstract

A rapid rise in the cytosolic free Ca2+ concentration due to influx of extracellular Ca2+ or mobilization from intracellular stores is the primary trigger for exocytosis from secretory cells. Our understanding as to the precise role of Ca2+ mobilization has been complicated by the presence of several types of Ca2+ stores in most cells. We now demonstrate that overexpression of the type 3 inositol 1,4,5-trisphosphate (IP3) receptor in insulin-secreting beta TC-3 cells results in the creation of a unique IP3-sensitive Ca2+ pool, restricted to the insulin secretory granules of these cells.

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Year:  1994        PMID： 7961623

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  19 in total

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Review 2.  Pediatric endocrine disorders of energy balance.

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Journal:  Rev Endocr Metab Disord       Date:  2005-12       Impact factor: 6.514

3.  Stable overexpression of the type-1 inositol 1,4,5-trisphosphate receptor in L fibroblasts: subcellular distribution and functional consequences.

Authors:  J J Mackrill; R A Wilcox; A Miyawaki; K Mikoshiba; S R Nahorski; R A Challiss
Journal:  Biochem J       Date:  1996-09-15       Impact factor: 3.857

4.  Differential regulation of types-1 and -3 inositol trisphosphate receptors by cytosolic Ca2+.

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Journal:  Biochem J       Date:  1997-12-15       Impact factor: 3.857

5.  Effects of extracellular calcium on electrical bursting and intracellular and luminal calcium oscillations in insulin secreting pancreatic beta-cells.

Authors:  T R Chay
Journal:  Biophys J       Date:  1997-09       Impact factor: 4.033

6.  Evidence that zymogen granules do not function as an intracellular Ca2+ store for the generation of the Ca2+ signal in rat parotid acinar cells.

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7.  Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+) signaling, and insulin secretion in the anx7(+/-) knockout mouse.

Authors:  M Srivastava; I Atwater; M Glasman; X Leighton; G Goping; H Caohuy; G Miller; J Pichel; H Westphal; D Mears; E Rojas; H B Pollard
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-23       Impact factor: 11.205

8.  Inositol 1,4,5-trisphosphate receptor subtype 3 in pancreatic islet cell secretory granules revisited.

Authors:  M Ravazzola; P A Halban; L Orci
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-02       Impact factor: 11.205

9.  Ca2+ and calmodulin differentially modulate myo-inositol 1,4, 5-trisphosphate (IP3)-binding to the recombinant ligand-binding domains of the various IP3 receptor isoforms.

Authors:  S Vanlingen; H Sipma; P De Smet; G Callewaert; L Missiaen; H De Smedt; J B Parys
Journal:  Biochem J       Date:  2000-03-01       Impact factor: 3.857

10.  Effect of M-phase kinase phosphorylations on type 1 inositol 1,4,5-trisphosphate receptor-mediated Ca2+ responses in mouse eggs.

Authors:  Nan Zhang; Sook Young Yoon; Jan B Parys; Rafael A Fissore
Journal:  Cell Calcium       Date:  2015-08-01       Impact factor: 6.817
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