| Literature DB >> 7960544 |
T Nakada1, Y Kubota, I Sasagawa, H Suzuki, M Watanabe, Y Suzuki.
Abstract
The concentrations of collagen, non-collagenous protein and elastin in ventral and dorsolateral prostates in oestradiol-17 beta-treated rats were higher than in vehicle-treated rats. The in vivo incorporation rates of 3H-proline into these connective tissue proteins in ventral and dorsolateral prostates were reduced following oestradiol-17 beta-treatment. The degradation rate of 3H-proline incorporated into each connective tissue protein was lowest in oestradiol-17 beta-treated animals. These findings indicate that the accumulation of collagen, non-collagenous protein and elastin in prostates of oestradiol-17 beta-treated rats can be largely accounted for by the suppressed degradation of biosynthesis of these connective tissue proteins.Entities:
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Year: 1994 PMID： 7960544 DOI： 10.1007/BF02768217
Source DB: PubMed Journal: Int Urol Nephrol ISSN： 0301-1623 Impact factor: 2.370