Literature DB >> 7960411

The effect of EGb 761 on retinal lipid peroxidation and glutathione peroxidase level in experimental lens induced uveitis.

A Bilgihan1, A Aricioğlu, K Bilgihan, M Onol, B Hasanreisoğlu, N Türközkan.   

Abstract

An acute lens-induced necrotizing intraocular inflammation was produced in pigmented guinea pigs. Treatment of these animals by 100 mg/kg/day EGb 761 a free oxygen radical scavenger for 10 days, reduced retinal lipid peroxidation (p > 0.05) and increased the retinal glutathione peroxidase level (p > 0.05). Although not significantly, these findings suggest that EGb 761 could be combined with other antiinflammatory drugs and may be beneficial in the treatment of uveitis.

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Year:  1994        PMID: 7960411     DOI: 10.1007/BF00919409

Source DB:  PubMed          Journal:  Int Ophthalmol        ISSN: 0165-5701            Impact factor:   2.031


  22 in total

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Authors:  B M Babior
Journal:  N Engl J Med       Date:  1978-03-23       Impact factor: 91.245

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Authors:  K C Bhuyan; D K Bhuyan
Journal:  Biochim Biophys Acta       Date:  1977-05-26

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Authors:  T Mittag
Journal:  Exp Eye Res       Date:  1984-12       Impact factor: 3.467

Review 4.  Free radicals and antioxidants in the pathogenesis of eye diseases.

Authors:  G E Marak; Y de Kozak; J P Faure
Journal:  Adv Exp Med Biol       Date:  1990       Impact factor: 2.622

5.  Ginkgo biloba extract inhibits oxygen species production generated by phorbol myristate acetate stimulated human leukocytes.

Authors:  J Pincemail; A Thirion; M Dupuis; P Braquet; K Drieu; C Deby
Journal:  Experientia       Date:  1987-02-15

6.  Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.

Authors:  D E Paglia; W N Valentine
Journal:  J Lab Clin Med       Date:  1967-07

7.  Modulation of lens-induced uveitis by superoxide dismutase.

Authors:  N A Rao; A J Calandra; A Sevanian; B Bowe; J M Delmage; G E Marak
Journal:  Ophthalmic Res       Date:  1986       Impact factor: 2.892

8.  Histochemical localization of superoxide production in experimental autoimmune uveitis.

Authors:  D C Gritz; C Montes; L R Atalla; G S Wu; A Sevanian; N A Rao
Journal:  Curr Eye Res       Date:  1991-10       Impact factor: 2.424

9.  The distribution of peroxide regulating enzymes in the canine eye.

Authors:  D Armstrong; G Santangelo; E Connole
Journal:  Curr Eye Res       Date:  1981       Impact factor: 2.424

10.  Immune complex induced generation of oxygen metabolites by human neutrophils.

Authors:  S J Weiss; P A Ward
Journal:  J Immunol       Date:  1982-07       Impact factor: 5.422

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