Literature DB >> 7959684

Fluorescence in situ hybridization reveals a break in the alpha-satellite DNA of chromosome 1 in a family with a balanced whole-arm translocation.

C H Gravholt1, M Caprani, U Friedrich.   

Abstract

We have characterized a whole-arm translocation involving chromosomes 1 and 19 by traditional cytogenetic methods and fluorescence in situ hybridization with chromosome-specific alpha-satellite and whole-chromosome painting probes, and different satellite III DNA probes. We have identified a break in the alpha-satellite DNA region of chromosome 1, with division of this material into two alpha-satellite DNA blocks. This leaves one translocation chromosome with truncated alpha-satellite DNA from chromosome 1 and the other translocation chromosome with all the alpha-satellite DNA from chromosome 19 and truncated alpha-satellite DNA from chromosome 1. We speculate whether the recombination event observed has taken place in tetraplex structures of satellite III DNA interspersed between alpha-satellite DNA.

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Year:  1994        PMID： 7959684     DOI： 10.1007/BF00211015

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  19 in total

Review 1.  The possibility of latent centromeres and a proposed nomenclature system for total chromosome and whole arm translocations.

Authors:  T C Hsu; S Pathak; T R Chen
Journal:  Cytogenet Cell Genet       Date:  1975

2.  Breakpoints in Robertsonian translocations are localized to satellite III DNA by fluorescence in situ hybridization.

Authors:  C H Gravholt; U Friedrich; M Caprani; A L Jørgensen
Journal:  Genomics       Date:  1992-12       Impact factor: 5.736

3.  Fluorescence in situ hybridization (FISH) of a whole-arm translocation involving chromosomes 18 and 20 with alpha-satellite DNA probes: detection of a centromeric DNA break?

Authors:  E S Cantú; T A Khan; G S Pai
Journal:  Am J Med Genet       Date:  1992-10-01

4.  Crystal structure of four-stranded Oxytricha telomeric DNA.

Authors:  C Kang; X Zhang; R Ratliff; R Moyzis; A Rich
Journal:  Nature       Date:  1992-03-12       Impact factor: 49.962

5.  Beta satellite DNA: characterization and localization of two subfamilies from the distal and proximal short arms of the human acrocentric chromosomes.

Authors:  G M Greig; H F Willard
Journal:  Genomics       Date:  1992-03       Impact factor: 5.736

6.  The organisation of repetitive DNA sequences on human chromosomes with respect to the kinetochore analysed using a combination of oligonucleotide primers and CREST anticentromere serum.

Authors:  A Mitchell; P Jeppesen; D Hanratty; J Gosden
Journal:  Chromosoma       Date:  1992-03       Impact factor: 4.316

7.  Centromeres without kinetochore proteins. Another mechanism for origin of aneuploidy in neoplasia.

Authors:  B K Vig; K L Sternes
Journal:  Cancer Genet Cytogenet       Date:  1991-02

8.  Balanced reciprocal whole-arm translocation t(1;19) in three generations.

Authors:  A M Schober; C Fonatsch
Journal:  Hum Genet       Date:  1978-06-27       Impact factor: 4.132

9.  Identification and characterization of a nuclease activity specific for G4 tetrastranded DNA.

Authors:  Z Liu; J D Frantz; W Gilbert; B K Tye
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-15       Impact factor: 11.205

10.  Cloning of human satellite III DNA: different components are on different chromosomes.

Authors:  H J Cooke; J Hindley
Journal:  Nucleic Acids Res       Date:  1979-07-25       Impact factor: 16.971
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  1 in total

1.  Familial whole-arm translocations (1;19), (9;13), and (12;21): a review of 101 constitutional exchanges.

Authors:  Alejandra Vázquez-Cárdenas; Ana I Vásquez-Velásquez; Patricio Barros-Núñez; Johana Mantilla-Capacho; Mariano Rocchi; Horacio Rivera
Journal:  J Appl Genet       Date:  2007       Impact factor: 3.240
  1 in total

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