Literature DB >> 7958952

Overexpression of c-myc precedes amplification of the gene encoding dihydrofolate reductase.

S Mai1.   

Abstract

An experimentally inducible model system was generated in which Chinese hamster ovary cells (CHO-9) were stably transfected with an inducible c-myc cDNA. The induction of c-myc in these transfectants is followed by the enhanced binding of c-Myc/Max-containing protein complexes to 5'flanking E-box sequences of the gene encoding dihydrofolate reductase (DHFR). Moreover, DHFR is transiently amplified. The inappropriate overproduction of the oncoprotein, therefore, seems to plays a role in induced DHFR amplification.

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Year:  1994        PMID： 7958952     DOI： 10.1016/0378-1119(94)90696-3

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  15 in total

1.  Chromosomal and extrachromosomal instability of the cyclin D2 gene is induced by Myc overexpression.

Authors:  S Mai; J Hanley-Hyde; G J Rainey; T I Kuschak; J T Paul; T D Littlewood; H Mischak; L M Stevens; D W Henderson; J F Mushinski
Journal:  Neoplasia       Date:  1999-08       Impact factor: 5.715

2.  Low expression of miR-let-7a promotes cell growth and invasion through the regulation of c-Myc in oral squamous cell carcinoma.

Authors:  Chunyang Luo; Jiyong Zhang; Yi Zhang; Xiao Zhang; Yinan Chen; Weimin Fan
Journal:  Cell Cycle       Date:  2020-06-28       Impact factor: 4.534

3.  c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus.

Authors:  Sherif F Louis; Bart J Vermolen; Yuval Garini; Ian T Young; Amanda Guffei; Zelda Lichtensztejn; Fabien Kuttler; Tony C Y Chuang; Sharareh Moshir; Virginie Mougey; Alice Y C Chuang; Paul Donald Kerr; Thierry Fest; Petra Boukamp; Sabine Mai
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-27       Impact factor: 11.205

Review 4.  Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis.

Authors:  Daniel Diolaiti; Lisa McFerrin; Patrick A Carroll; Robert N Eisenman
Journal:  Biochim Biophys Acta       Date:  2014-05-22

5.  Genomic instability in MycER-activated Rat1A-MycER cells.

Authors:  S Mai; M Fluri; D Siwarski; K Huppi
Journal:  Chromosome Res       Date:  1996-08       Impact factor: 5.239

6.  Deregulated expression of c-Myc in a translocation-negative plasmacytoma on extrachromosomal elements that carry IgH and myc genes.

Authors:  F Wiener; T I Kuschak; S Ohno; S Mai
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-23       Impact factor: 11.205

7.  Overexpression of c-Myc alters G(1)/S arrest following ionizing radiation.

Authors:  Joon-Ho Sheen; Robert B Dickson
Journal:  Mol Cell Biol       Date:  2002-03       Impact factor: 4.272

8.  Activation of rat alveolar macrophage-derived latent transforming growth factor beta-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36.

Authors:  T Yehualaeshet; R O'Connor; J Green-Johnson; S Mai; R Silverstein; J E Murphy-Ullrich; N Khalil
Journal:  Am J Pathol       Date:  1999-09       Impact factor: 4.307

9.  The c-myc protein represses the lambda 5 and TdT initiators.

Authors:  S Mai; I L Mårtensson
Journal:  Nucleic Acids Res       Date:  1995-01-11       Impact factor: 16.971

10.  Unbalanced replication as a major source of genetic instability in cancer cells.

Authors:  Daniel Corcos
Journal:  Am J Blood Res       Date:  2012-10-20
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