Literature DB >> 7958500

Parental origin of diabetes-associated HLA types in sibling pairs with type I diabetes.

S C Bain1, B R Rowe, A H Barnett, J A Todd.   

Abstract

Genetic susceptibility to type I diabetes is partly determined by genes located in the human leukocyte antigen (HLA) region on chromosome 6. It has been claimed that the transmission of HLA-encoded susceptibility is influenced by parental sex. Fathers are reported to transmit HLA-DR4 haplotypes more frequently to their diabetic offspring than mothers. More recently, it has been suggested that the presence of HLA-DR4 in a mother may influence susceptibility in her offspring, even when it is not inherited. We have analyzed 172 multiplex diabetic pedigrees from the U.K. and find no evidence to support an important effect of parental sex on the inheritance of HLA-encoded susceptibility. Examination of a further 110 pedigrees from the U.S. supports this finding. These results have important implications for strategies involving genetic screening for type I diabetes.

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Year:  1994        PMID： 7958500     DOI： 10.2337/diab.43.12.1462

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  10 in total

Review 1.  Genetic predisposition to IDDM.

Authors:  S Caillat-Zucman; J F Bach
Journal:  Clin Rev Allergy Immunol       Date:  2000-12       Impact factor: 8.667

2.  Genes mediating environment interactions in type 1 diabetes.

Authors:  Erik Biros; Margaret A Jordan; Alan G Baxter
Journal:  Rev Diabet Stud       Date:  2006-02-10

3.  The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families.

Authors:  J A Noble; A M Valdes; M Cook; W Klitz; G Thomson; H A Erlich
Journal:  Am J Hum Genet       Date:  1996-11       Impact factor: 11.025

Review 4.  Type 1 diabetes mellitus and multiple sclerosis: common etiological features.

Authors:  Adam E Handel; Lahiru Handunnetthi; George C Ebers; Sreeram V Ramagopalan
Journal:  Nat Rev Endocrinol       Date:  2009-11-03       Impact factor: 43.330

5.  No difference in the parental origin of susceptibility HLA class II haplotypes among Norwegian patients with insulin-dependent diabetes mellitus.

Authors:  D E Undlien; H E Akselsen; G Joner; K Dahl-Jorgensen; O Aagenaes; O Sovik; E Thorsby; K S Rønningen
Journal:  Am J Hum Genet       Date:  1995-12       Impact factor: 11.025

6.  A powerful test of parent-of-origin effects for quantitative traits using haplotypes.

Authors:  Rui Feng; Yinghua Wu; Gun Ho Jang; Jose M Ordovas; Donna Arnett
Journal:  PLoS One       Date:  2011-12-13       Impact factor: 3.240

7.  Mutation screening of spastin, atlastin, and REEP1 in hereditary spastic paraplegia.

Authors:  D S McCorquodale; U Ozomaro; J Huang; G Montenegro; A Kushman; L Citrigno; J Price; F Speziani; M A Pericak-Vance; S Züchner
Journal:  Clin Genet       Date:  2011-06       Impact factor: 4.438

8.  Analysis of maternal-offspring HLA compatibility, parent-of-origin and non-inherited maternal effects for the classical HLA loci in type 1 diabetes.

Authors:  P G Bronson; P P Ramsay; G Thomson; L F Barcellos
Journal:  Diabetes Obes Metab       Date:  2009-02       Impact factor: 6.577

9.  Newborn screening for HLA markers associated with IDDM: diabetes autoimmunity study in the young (DAISY).

Authors:  M Rewers; T L Bugawan; J M Norris; A Blair; B Beaty; M Hoffman; R S McDuffie; R F Hamman; G Klingensmith; G S Eisenbarth; H A Erlich
Journal:  Diabetologia       Date:  1996-07       Impact factor: 10.122

Review 10.  Genetic analysis of type 1 diabetes using whole genome approaches.

Authors:  J A Todd
Journal:  Proc Natl Acad Sci U S A       Date:  1995-09-12       Impact factor: 11.205
  10 in total

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