Literature DB >> 7957940

The pathway of CO binding to cytochrome c oxidase. Can the gateway be closed?

B C Hill1.   

Abstract

Addition of cyanide to the CO complex of cytochrome oxidase reduces the apparent photosensitivity of the Fe-CO bond. This effect is not seen with azide, or when cyanide is added to ferromyoglobin-CO. It is proposed that cyanide binds to CuB, and restricts the passage of CO out of the protein. This restriction favors geminate recombination of CO and ferrocytochrome a3, thereby lowering the apparent quantum yield for CO photolysis. The apparent Kd of cyanide for CuB is 15.4 mM. These data support a direct role for CuB in ligand binding by cytochrome c oxidase.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7957940     DOI： 10.1016/0014-5793(94)01140-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  4 in total

1.  Thermodynamic volume cycles for electron transfer in the cytochrome c oxidase and for the binding of cytochrome c to cytochrome c oxidase.

Authors:  J A Kornblatt; M J Kornblatt; I Rajotte; G H Hoa; P C Kahn
Journal:  Biophys J       Date:  1998-07       Impact factor: 4.033

2.  Population pharmacokinetic analysis of carboxyhaemoglobin concentrations in adult cigarette smokers.

Authors:  Carol Cronenberger; Diane R Mould; Hans-Juergen Roethig; Mohamadi Sarkar
Journal:  Br J Clin Pharmacol       Date:  2007-08-31       Impact factor: 4.335

3.  Antagonism of nitric oxide toward the inhibition of cytochrome c oxidase by carbon monoxide and cyanide.

Authors:  Linda L Pearce; Elisenda Lopez Manzano; Sandra Martinez-Bosch; Jim Peterson
Journal:  Chem Res Toxicol       Date:  2008-11       Impact factor: 3.739

4.  Ligand trapping by cytochrome c oxidase: implications for gating at the catalytic center.

Authors:  Dzmitry Parul; Graham Palmer; Marian Fabian
Journal:  J Biol Chem       Date:  2009-12-25       Impact factor: 5.157
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.