Literature DB >> 7957926

Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain.

L A Bare1, E Mansson, D Yang.   

Abstract

A partial mu opioid receptor gene was isolated from a human genomic library using a mouse delta opioid receptor cDNA as a probe. Using information from this genomic clone and the published human mu receptor, MOR1, a cDNA was isolated from SK-N-SH mRNA that codes for a variant of the MOR1 mRNA, MOR1A. The presence of MOR1A is also shown in human brain using RT-PCR. MOR1A differs from MOR1 in that the 3' terminal intron has not been removed. An in-frame termination codon is found four amino acids after the 5' consensus splice site, making MOR1A eight amino acids shorter than MOR1. Both receptors show similar ligand binding and coupling to cAMP in CHO-K1 cells. The C-terminal differences between MOR1 and MOR1A could have effects on receptor coupling or receptor transport and localization.

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Year:  1994        PMID： 7957926     DOI： 10.1016/0014-5793(94)01129-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  43 in total

1.  Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm gene.

Authors:  Y X Pan; J Xu; L Mahurter; E Bolan; M Xu; G W Pasternak
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-20       Impact factor: 11.205

Review 2.  Post-transcriptional regulation of opioid receptors in the nervous system.

Authors:  Li-Na Wei; Ping-Yee Law; Horace H Loh
Journal:  Front Biosci       Date:  2004-05-01

3.  Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants.

Authors:  Susruta Majumdar; Joan Subrath; Valerie Le Rouzic; Lisa Polikar; Maxim Burgman; Kuni Nagakura; Julie Ocampo; Nathan Haselton; Anna R Pasternak; Steven Grinnell; Ying-Xian Pan; Gavril W Pasternak
Journal:  J Med Chem       Date:  2012-07-16       Impact factor: 7.446

4.  Splice variation of the mu-opioid receptor and its effect on the action of opioids.

Authors:  Sophy K Gretton; Joanne Droney
Journal:  Br J Pain       Date:  2014-11

5.  Molecular basis of cellular localization of poly C binding protein 1 in neuronal cells.

Authors:  Andrea M Berry; Kelly E Flock; Horace H Loh; Jane L Ko
Journal:  Biochem Biophys Res Commun       Date:  2006-09-12       Impact factor: 3.575

6.  Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence.

Authors:  Huiping Zhang; Xingguang Luo; Henry R Kranzler; Jaakko Lappalainen; Bao-Zhu Yang; Evgeny Krupitsky; Edwin Zvartau; Joel Gelernter
Journal:  Hum Mol Genet       Date:  2006-02-13       Impact factor: 6.150

7.  Stabilization of the μ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action.

Authors:  Jin Xu; Ming Xu; Taylor Brown; Grace C Rossi; Yasmin L Hurd; Charles E Inturrisi; Gavril W Pasternak; Ying-Xian Pan
Journal:  J Biol Chem       Date:  2013-06-11       Impact factor: 5.157

8.  Bioinformatic analysis of the human mu opioid receptor (OPRM1) splice and polymorphic variants.

Authors:  Lili Xin; Zaijie Jim Wang
Journal:  AAPS PharmSci       Date:  2002

9.  Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene.

Authors:  Jin Xu; Mingming Xu; Yasmin L Hurd; Gavril W Pasternak; Ying-Xian Pan
Journal:  J Neurochem       Date:  2008-12-10       Impact factor: 5.372

10.  Effects of trichostatin A on neuronal mu-opioid receptor gene expression.

Authors:  Ying-Chih Lin; Kelly E Flock; Ryan J Cook; Amanda J Hunkele; Horace H Loh; Jane L Ko
Journal:  Brain Res       Date:  2008-10-11       Impact factor: 3.252
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