| Literature DB >> 7957867 |
J P Spencer1, A Jenner, O I Aruoma, P J Evans, H Kaur, D T Dexter, P Jenner, A J Lees, D C Marsden, B Halliwell.
Abstract
Oxidative DNA damage can cause mutation and cell death. We show that L-DOPA, dopamine and 3-O-methyl-DOPA cause extensive oxidative DNA damage in the presence of H2O2 and traces of copper ions. 8-Hydroxyguanine is the major product. Iron ions were much less effective and manganese ions did not catalyse DNA damage. We propose that copper ion release, in the presence of L-DOPA and its metabolites, may be an important mechanism of neurotoxicity, e.g. in Parkinson's disease and amyotrophic lateral sclerosis.Entities:
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Year: 1994 PMID： 7957867 DOI： 10.1016/0014-5793(94)01056-0
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124