Literature DB >> 7957617

Nitric oxide as mediator of the gastroprotection by cholecystokinin-8 and pentagastrin.

T Stroff1, N Lambrecht, B M Peskar.   

Abstract

Cholecystokinin-8 and pentagastrin protect against ethanol-induced gastric mucosal lesions in rats. The protective effect is antagonized by the nitric oxide (NO) synthase inhibitor, NG-nitro-L-arginine. The inhibitory action of NG-nitro-L-arginine is reversed by L-arginine, but not D-arginine. The findings suggest that NO is involved in the gastroprotection induced by both peptides.

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Year:  1994        PMID: 7957617     DOI: 10.1016/0014-2999(94)90019-1

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN: 0014-2999            Impact factor:   4.432


  2 in total

1.  Cyclooxygenase inhibition attenuates cholecystokinin-induced gastroprotection.

Authors:  D W Mercer; G S Smith; T A Miller
Journal:  Dig Dis Sci       Date:  1998-03       Impact factor: 3.199

2.  Effects of cholecystokinin on gastric injury and gastric mucosal blood flow.

Authors:  J M Cross; L Chang; D W Mercer
Journal:  J Gastrointest Surg       Date:  1998 Mar-Apr       Impact factor: 3.267

  2 in total

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