Literature DB >> 7957354

Prevention of renal tubule re-absorption of radiometal (indium-111) labelled Fab fragment of a monoclonal antibody in mice by systemic administration of lysine.

M V Pimm1, S J Gribben.   

Abstract

Systemic administration of lysine to mice injected with indium-111-labelled Fab fragment of a monoclonal antibody has been shown to reduce renal uptake/retention of the radiometal. This treatment should be applicable to clinical immunoscintigraphy and radioimmunotherapy with radiometal-labelled antibody fragments.

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Year:  1994        PMID： 7957354     DOI： 10.1007/BF00285590

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  7 in total

1.  Studies on renal tubular protein reabsorption: partial and near complete inhibition by certain amino acids.

Authors:  C E Mogensen
Journal:  Scand J Clin Lab Invest       Date:  1977-10       Impact factor: 1.713

2.  A comparison of iodine and indium labelled anti CEA intact antibody, F(ab)2 and Fab fragments by imaging tumour xenografts.

Authors:  S M Andrew; A C Perkins; M V Pimm; R W Baldwin
Journal:  Eur J Nucl Med       Date:  1988

3.  Kinetics and tissue distribution of the radiolabeled chimeric monoclonal antibody MOv18 IgG and F(ab')2 fragments in ovarian carcinoma patients.

Authors:  M R Buist; P Kenemans; W den Hollander; J B Vermorken; C J Molthoff; C W Burger; T J Helmerhorst; J P Baak; J C Roos
Journal:  Cancer Res       Date:  1993-11-15       Impact factor: 12.701

4.  Differential metabolic patterns of iodinated versus radiometal chelated anticarcinoma single-chain Fv molecules.

Authors:  M E Schott; D E Milenic; T Yokota; M Whitlow; J F Wood; W A Fordyce; R C Cheng; J Schlom
Journal:  Cancer Res       Date:  1992-11-15       Impact factor: 12.701

5.  Intracellular metabolism of indium-111-DTPA-labeled receptor targeted proteins.

Authors:  J R Duncan; M J Welch
Journal:  J Nucl Med       Date:  1993-10       Impact factor: 10.057

6.  Preclinical evaluation of 67Cu-labeled intact and fragmented anti-colon carcinoma monoclonal antibody MAb35.

Authors:  A Smith; R Alberto; P Blaeuenstein; I Novak-Hofer; H R Maecke; P A Schubiger
Journal:  Cancer Res       Date:  1993-12-01       Impact factor: 12.701

7.  Amino acid infusion blocks renal tubular uptake of an indium-labelled somatostatin analogue.

Authors:  P J Hammond; A F Wade; M E Gwilliam; A M Peters; M J Myers; S G Gilbey; S R Bloom; J Calam
Journal:  Br J Cancer       Date:  1993-06       Impact factor: 7.640
  7 in total
  6 in total

Review 1.  Imaging in targeted delivery of therapy to cancer.

Authors:  Gairin Dancey; Richard H Begent; Tim Meyer
Journal:  Target Oncol       Date:  2009-10-08       Impact factor: 4.493

2.  Synthesis and in vitro and in vivo evaluation of hypoxia-enhanced 111In-bombesin conjugates for prostate cancer imaging.

Authors:  Zhengyuan Zhou; Nilesh K Wagh; Sunny M Ogbomo; Wen Shi; Yinnong Jia; Susan K Brusnahan; Jered C Garrison
Journal:  J Nucl Med       Date:  2013-07-29       Impact factor: 10.057

3.  Evaluation in vitro and in rats of 161Tb-DTPA-octreotide, a somatostatin analogue with potential for intraoperative scanning and radiotherapy.

Authors:  M de Jong; W A Breeman; B F Bernard; E J Rolleman; L J Hofland; T J Visser; B Setyono-Han; W H Bakker; M E van der Pluijm; E P Krenning
Journal:  Eur J Nucl Med       Date:  1995-07

Review 4.  Synthetic nanoparticles for delivery of radioisotopes and radiosensitizers in cancer therapy.

Authors:  Jun Zhao; Min Zhou; Chun Li
Journal:  Cancer Nanotechnol       Date:  2016-11-16

5.  Pancreatic imaging using an antibody fragment targeting the zinc transporter type 8: a direct comparison with radio-iodinated Exendin-4.

Authors:  Olof Eriksson; Olle Korsgren; Ram Kumar Selvaraju; Marjorie Mollaret; Yann de Boysson; Fabrice Chimienti; Mohamed Altai
Journal:  Acta Diabetol       Date:  2017-10-24       Impact factor: 4.280

6.  Albumin-derived peptides efficiently reduce renal uptake of radiolabelled peptides.

Authors:  Erik Vegt; Annemarie Eek; Wim J G Oyen; Marion de Jong; Martin Gotthardt; Otto C Boerman
Journal:  Eur J Nucl Med Mol Imaging       Date:  2009-09-01       Impact factor: 9.236
  6 in total

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