Literature DB >> 7956363

Assignment of the human heart tetrodotoxin-resistant voltage-gated Na+ channel alpha-subunit gene (SCN5A) to band 3p21.

A L George1, T A Varkony, H A Drabkin, J Han, J F Knops, W H Finley, G B Brown, D C Ward, M Haas.   

Abstract

The chromosomal location of SCN5A, the gene encoding the principal voltage-gated Na+ channel expressed in human heart, has been determined by three independent methodologies: somatic cell hybrid mapping, chromosomal microdissection-polymerase chain reaction, and fluorescence in situ hybridization. The SCN5A gene was assigned to the short arm of chromosome 3 (band 3p21) by all three approaches. These data are further evidence that striated muscle Na+ channel genes are dispersed in the genome.

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Year:  1995        PMID: 7956363     DOI: 10.1159/000133892

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN: 0301-0171


  18 in total

Review 1.  Computational biology in the study of cardiac ion channels and cell electrophysiology.

Authors:  Yoram Rudy; Jonathan R Silva
Journal:  Q Rev Biophys       Date:  2006-07-19       Impact factor: 5.318

2.  RBM25/LUC7L3 function in cardiac sodium channel splicing regulation of human heart failure.

Authors:  Ge Gao; Samuel C Dudley
Journal:  Trends Cardiovasc Med       Date:  2012-08-31       Impact factor: 6.677

3.  Replication of SCN5A Associations with Electrocardio-graphic Traits in African Americans from Clinical and Epidemiologic Studies.

Authors:  Janina M Jeff; Kristin Brown-Gentry; Robert Goodloe; Marylyn D Ritchie; Joshua C Denny; Abel N Kho; Loren L Armstrong; Bob McClellan; Ping Mayo; Melissa Allen; Hailing Jin; Niloufar B Gillani; Nathalie Schnetz-Boutaud; Holli H Dilks; Melissa A Basford; Jennifer A Pacheco; Gail P Jarvik; Rex L Chisholm; Dan M Roden; M Geoffrey Hayes; Dana C Crawford
Journal:  Evol Comput Mach Learn Data Min Bioinform       Date:  2014

4.  Characterization of human cardiac Na+ channel mutations in the congenital long QT syndrome.

Authors:  D W Wang; K Yazawa; A L George; P B Bennett
Journal:  Proc Natl Acad Sci U S A       Date:  1996-11-12       Impact factor: 11.205

5.  Pharmacological targeting of long QT mutant sodium channels.

Authors:  D W Wang; K Yazawa; N Makita; A L George; P B Bennett
Journal:  J Clin Invest       Date:  1997-04-01       Impact factor: 14.808

6.  Long QT syndrome: from channels to cardiac arrhythmias.

Authors:  Arthur J Moss; Robert S Kass
Journal:  J Clin Invest       Date:  2005-08       Impact factor: 14.808

Review 7.  Brugada and long QT-3 syndromes: two phenotypes of the sodium channel disease.

Authors:  Ijaz A Khan; Chandra K Nair
Journal:  Ann Noninvasive Electrocardiol       Date:  2004-07       Impact factor: 1.468

Review 8.  Caveolae, ion channels and cardiac arrhythmias.

Authors:  Ravi C Balijepalli; Timothy J Kamp
Journal:  Prog Biophys Mol Biol       Date:  2009-01-30       Impact factor: 3.667

9.  Distinct local anesthetic affinities in Na+ channel subtypes.

Authors:  D W Wang; L Nie; A L George; P B Bennett
Journal:  Biophys J       Date:  1996-04       Impact factor: 4.033

10.  SCN5A splicing variants and the possibility of predicting heart failure-associated arrhythmia.

Authors:  Ge Gao; Samuel C Dudley
Journal:  Expert Rev Cardiovasc Ther       Date:  2013-02
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